| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
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| Ligand | BDBM50393642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1683759 |
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| IC50 | 60000±n/a nM |
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| Citation |  Ohno, H; Honda, M; Hamada, N; Miyagaki, J; Iwata, A; Otsuki, K; Maruyama, T; Nakamura, S; Nakanishi, I; Inuki, S; Fujii, N; Oishi, S Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B. Bioorg Med Chem25:3046-3052 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 2 |
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| Name: | Sphingosine kinase 2 |
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| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
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| Type: | Protein |
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| Mol. Mass.: | 69221.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NRA0 |
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| Residue: | 654 |
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| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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| BDBM50393642 |
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| n/a |
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| Name | BDBM50393642 |
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| Synonyms: | CHEMBL2158685 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H25ClN2O |
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| Mol. Mass. | 380.91 |
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| SMILES | Clc1ccc(cc1)C12CC3CC(CC(C3)(C1)C(=O)NCc1ccncc1)C2 |TLB:14:9:26:15.13.12,14:13:8.9.10:26,THB:16:13:8:10.11.26,16:13:8.9.10:26,12:13:8:10.11.26,12:11:8:15.14.13| |
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| Structure | 
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