| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
|---|
| Ligand | BDBM50175277 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1683753 |
|---|
| Ki | 14100±n/a nM |
|---|
| Citation |  Ohno, H; Honda, M; Hamada, N; Miyagaki, J; Iwata, A; Otsuki, K; Maruyama, T; Nakamura, S; Nakanishi, I; Inuki, S; Fujii, N; Oishi, S Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B. Bioorg Med Chem25:3046-3052 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 2 |
|---|
| Name: | Sphingosine kinase 2 |
|---|
| Synonyms: | SK 2 | SPHK2_MOUSE | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase 2 (SPHK2) | Sphk2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 65617.92 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | Q9JIA7 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLD
EVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTFRADGATTYEENRAEAQRWAT
ALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSF
NLIQTERQNHARELVQGLSLSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLP
CGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSV
AWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLP
RAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSPGSPEPLPDLSLNGGGPELTG
DWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPV
DHLLPPLGSPLPQDWVTIEGEFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGIS
RAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVH
PGLATLLTGPAGQKPQA
|
|
|
|---|
| BDBM50175277 |
|---|
| n/a |
|---|
| Name | BDBM50175277 |
|---|
| Synonyms: | CHEMBL3809675 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H37ClN4O |
|---|
| Mol. Mass. | 433.03 |
|---|
| SMILES | Cl.CCCCCCCCCCCCc1ccc(cc1)-c1noc(n1)C1(CC1)C(N)=N |
|---|
| Structure | 
|
|---|
Search and Browse
