Ki Summary

Reaction Details

Report a problem with these data

Target

Serine/threonine-protein kinase pim-2

Ligand

BDBM50261827

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_1696473

IC50

6.0±n/a nM

Citation

Barberis, C; Moorcroft, N; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barrague, M; Erdman, P; Majid, T; Batchelor, J; Levit, M; Hebert, A; Shen, L; Moreno-Mazza, S; Wang, A Discovery of N-substituted 7-azaindoles as Pan-PIM kinase inhibitors - Lead series identification - Part II. Bioorg Med Chem Lett27:4735-4740 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Serine/threonine-protein kinase pim-2

Name:

Serine/threonine-protein kinase pim-2

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

34185.93

Organism:

Homo sapiens (Human)

Description:

Q9P1W9

Residue:

311

Sequence:

MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP

BDBM50261827

n/a

Name

BDBM50261827

Synonyms:

CHEMBL4070441

Type

Small organic molecule

Emp. Form.

C14H15Cl2IN4O

Mol. Mass.

453.106

SMILES

NC1CCC(CC1)n1c(I)c(Cl)c2c(Cl)cc(nc12)C(N)=O |(71.97,-24.68,;71.49,-23.21,;69.98,-22.89,;69.5,-21.44,;70.53,-20.3,;72.04,-20.6,;72.52,-22.06,;70.05,-18.83,;70.95,-17.58,;72.49,-17.57,;70.03,-16.34,;70.5,-14.87,;68.57,-16.82,;67.24,-16.06,;67.23,-14.52,;65.91,-16.83,;65.91,-18.37,;67.24,-19.15,;68.58,-18.37,;64.57,-19.14,;64.57,-20.68,;63.24,-18.37,)|

Structure