| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM168239 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1697749 |
|---|
| IC50 | 10.0±n/a nM |
|---|
| Citation |  Reich, SH; Sprengeler, PA; Chiang, GG; Appleman, JR; Chen, J; Clarine, J; Eam, B; Ernst, JT; Han, Q; Goel, VK; Han, EZR; Huang, V; Hung, INJ; Jemison, A; Jessen, KA; Molter, J; Murphy, D; Neal, M; Parker, GS; Shaghafi, M; Sperry, S; Staunton, J; Stumpf, CR; Thompson, PA; Tran, C; Webber, SE; Wegerski, CJ; Zheng, H; Webster, KR Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. J Med Chem61:3516-3540 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 51342.85 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BUB5 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAY
AKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRF
YLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPS
GLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMK
LNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPP
FVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAK
QRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENEL
AEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
|
|
|
|---|
| BDBM168239 |
|---|
| n/a |
|---|
| Name | BDBM168239 |
|---|
| Synonyms: | US9669031, 67 3,3,8-trimethyl-6-(pyrimidin-4-ylamino)-2H-imidazo[1,5-a]pyridine-1,5-dione (Cpd. No. 67) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H15N5O2 |
|---|
| Mol. Mass. | 285.3012 |
|---|
| SMILES | Cc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC2(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
