Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM50459625 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1766899 (CHEMBL4202146) |
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IC50 | 3.4±n/a nM |
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Citation | Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem61:9121-9131 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Synaptic vesicular amine transporter | VAT2 | VMAT2_MOUSE | Vesicular amine transporter 2 | Vmat2 |
Type: | PROTEIN |
Mol. Mass.: | 55751.56 |
Organism: | Mus musculus |
Description: | ChEMBL_118131 |
Residue: | 517 |
Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEI
QTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDC
PSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFA
FSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPP
FGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIA
AGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR
WLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSV
YGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKE
EKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD
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BDBM50459625 |
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n/a |
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Name | BDBM50459625 |
Synonyms: | CHEMBL4205254 |
Type | Small organic molecule |
Emp. Form. | C24H26FN3O4 |
Mol. Mass. | 439.4793 |
SMILES | CCOC(=O)C1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CCC1c1ccc(F)cc1 |
Structure |
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