| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
|---|
| Ligand | BDBM50459625 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1766899 (CHEMBL4202146) |
|---|
| IC50 | 3.39±n/a nM |
|---|
| Citation |  Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem61:9121-9131 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Synaptic vesicular amine transporter |
|---|
| Name: | Synaptic vesicular amine transporter |
|---|
| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Synaptic vesicular amine transporter | VAT2 | VMAT2_MOUSE | Vesicular amine transporter 2 | Vmat2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55751.56 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_118131 |
|---|
| Residue: | 517 |
|---|
| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEI
QTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDC
PSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFA
FSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPP
FGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIA
AGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR
WLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSV
YGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKE
EKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD
|
|
|
|---|
| BDBM50459625 |
|---|
| n/a |
|---|
| Name | BDBM50459625 |
|---|
| Synonyms: | CHEMBL4205254 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H26FN3O4 |
|---|
| Mol. Mass. | 439.4793 |
|---|
| SMILES | CCOC(=O)C1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CCC1c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
