| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Ligand | BDBM50459845 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1767310 (CHEMBL4219422) |
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| IC50 | >100000±n/a nM |
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| Citation |  Schiedel, M; Herp, D; Hammelmann, S; Swyter, S; Lehotzky, A; Robaa, D; Oláh, J; Ovádi, J; Sippl, W; Jung, M Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). J Med Chem61:482-491 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Name: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial |
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| Synonyms: | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3 |
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| Type: | Protein |
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| Mol. Mass.: | 43582.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NTG7 |
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| Residue: | 399 |
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| Sequence: | MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEP
LDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDK
GKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF
ELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIP
ASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQ
RFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDV
AQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
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| BDBM50459845 |
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| n/a |
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| Name | BDBM50459845 |
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| Synonyms: | CHEMBL4227437 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27N7O3S2 |
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| Mol. Mass. | 525.646 |
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| SMILES | COCCn1cc(COc2cccc(Cc3cnc(NC(=O)CSc4nc(C)cc(C)n4)s3)c2)nn1 |
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| Structure | 
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