| Reaction Details |
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 | Report a problem with these data |
| Target | TYR_PHOSPHATASE_2 domain-containing protein |
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| Ligand | BDBM50466478 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793231 (CHEMBL4265150) |
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| IC50 | 6200±n/a nM |
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| Citation |  Sens, L; de Souza, ACA; Pacheco, LA; Menegatti, ACO; Mori, M; Mascarello, A; Nunes, RJ; Terenzi, H Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors. Bioorg Med Chem26:5742-5750 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| TYR_PHOSPHATASE_2 domain-containing protein |
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| Name: | TYR_PHOSPHATASE_2 domain-containing protein |
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| Synonyms: | (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase) | MPtpB | PHOSPHOTYROSINE PROTEIN PHOSPHATASE PTPB | Phosphotyrosine protein phosphatase | Phosphotyrosine-protein phosphatase PTPB | Protein Tyrosine Phosphatase PTPB |
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| Type: | Hydrolase |
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| Mol. Mass.: | 30152.45 |
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| Organism: | Mycobacterium tuberculosis |
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| Description: | n/a |
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| Residue: | 276 |
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| Sequence: | MAVRELPGAWNFRDVADTATALRPGRLFRSSELSRLDDAGRATLRRLGITDVADLRSSRE
VARRGPGRVPDGIDVHLLPFPDLADDDADDSAPHETAFKRLLTNDGSNGESGESSQSIND
AATRYMTDEYRQFPTRNGAQRALHRVVTLLAAGRPVLTHCFAGKDRTGFVVALVLEAVGL
DRDVIVADYLRSNDSVPQLRARISEMIQQRFDTELAPEVVTFTKARLSDGVLGVRAEYLA
AARQTIDETYGSLGGYLRDAGISQATVNRMRGVLLG
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| BDBM50466478 |
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| n/a |
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| Name | BDBM50466478 |
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| Synonyms: | CHEMBL4288744 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15ClF3N3OS |
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| Mol. Mass. | 473.898 |
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| SMILES | FC(F)(F)c1ccc(Cl)c(c1)-c1ccc(\C=N\NC(=S)Nc2cccc3ccccc23)o1 |
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| Structure | 
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