| Reaction Details |
|---|
 | Report a problem with these data |
| Target | UDP-N-acetylenolpyruvoylglucosamine reductase |
|---|
| Ligand | BDBM50475602 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_328935 (CHEMBL859885) |
|---|
| IC50 | 5120±n/a nM |
|---|
| Citation |  Antane, S; Caufield, CE; Hu, W; Keeney, D; Labthavikul, P; Morris, K; Naughton, SM; Petersen, PJ; Rasmussen, BA; Singh, G; Yang, Y Pulvinones as bacterial cell wall biosynthesis inhibitors. Bioorg Med Chem Lett16:176-80 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| UDP-N-acetylenolpyruvoylglucosamine reductase |
|---|
| Name: | UDP-N-acetylenolpyruvoylglucosamine reductase |
|---|
| Synonyms: | MURB_ECOLI | MurB (E. coli) | UDP-N-acetylenolpyruvoylglucosamine reductase | UDP-N-acetylmuramate dehydrogenase | murB | yijB |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 37848.05 |
|---|
| Organism: | Escherichia coli K-12 (Enterobacteria) |
|---|
| Description: | E. coli MurB |
|---|
| Residue: | 342 |
|---|
| Sequence: | MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRG
TVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQ
NIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRL
PKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAET
AKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKS
EDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS
|
|
|
|---|
| BDBM50475602 |
|---|
| n/a |
|---|
| Name | BDBM50475602 |
|---|
| Synonyms: | CHEMBL199929 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H18O3 |
|---|
| Mol. Mass. | 390.43 |
|---|
| SMILES | OC1=C(C(=O)O\C1=C/c1ccc(cc1)-c1ccccc1)c1ccc2ccccc2c1 |t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
