Reaction Details |
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Target | Reverse transcriptase |
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Ligand | BDBM50478750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_534522 (CHEMBL984612) |
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IC50 | 1400±n/a nM |
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Citation | Cesarini, S; Spallarossa, A; Ranise, A; Bruno, O; La Colla, P; Secci, B; Collu, G; Loddo, R Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure-activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate. Bioorg Med Chem16:4173-85 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase |
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Name: | Reverse transcriptase |
Synonyms: | n/a |
Type: | Protein |
Mol. Mass.: | 29598.37 |
Organism: | Human immunodeficiency virus 1 |
Description: | Q9WKE8 |
Residue: | 254 |
Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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BDBM50478750 |
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n/a |
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Name | BDBM50478750 |
Synonyms: | CHEMBL471691 |
Type | Small organic molecule |
Emp. Form. | C17H19NO2S |
Mol. Mass. | 301.403 |
SMILES | CC(COc1ccccc1)OC(=S)Nc1ccc(C)cc1 |
Structure |
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