Reaction Details |
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Target | Integrase |
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Ligand | BDBM50479068 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_509633 (CHEMBL1003961) |
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IC50 | 14000±n/a nM |
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Citation | Zeng, LF; Jiang, XH; Sanchez, T; Zhang, HS; Dayam, R; Neamati, N; Long, YQ Novel dimeric aryldiketo containing inhibitors of HIV-1 integrase: effects of the phenyl substituent and the linker orientation. Bioorg Med Chem16:7777-87 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Integrase |
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Name: | Integrase |
Synonyms: | pol |
Type: | PROTEIN |
Mol. Mass.: | 32203.43 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_106649 |
Residue: | 288 |
Sequence: | FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
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BDBM50479068 |
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n/a |
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Name | BDBM50479068 |
Synonyms: | CHEMBL511423 |
Type | Small organic molecule |
Emp. Form. | C24H31NO5 |
Mol. Mass. | 413.5066 |
SMILES | CCCCCC12CCC(CC1)(CC2)C(=O)Nc1cccc(c1)C(=O)CC(=O)C(O)=O |
Structure |
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