| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Platelet-derived growth factor receptor alpha |
|---|
| Ligand | BDBM50501882 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1805765 (CHEMBL4305124) |
|---|
| IC50 | 7777±n/a nM |
|---|
| Citation |  Liu, X; Wang, B; Chen, C; Qi, Z; Zou, F; Wang, J; Hu, C; Wang, A; Ge, J; Liu, Q; Yu, K; Hu, Z; Jiang, Z; Wang, W; Wang, L; Wang, W; Ren, T; Bai, M; Liu, Q; Liu, J Discovery of ( E)- N J Med Chem62:5006-5024 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Platelet-derived growth factor receptor alpha |
|---|
| Name: | Platelet-derived growth factor receptor alpha |
|---|
| Synonyms: | Alpha-type platelet-derived growth factor receptor | PDGFR2 | PDGFRA | PDGFRalpha | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFR-alpha) | Platelet-derived growth factor receptor alpha (PDGFRA) | Platelet-derived growth factor receptor, alpha polypeptid | RHEPDGFRA |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 122633.38 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P16234 |
|---|
| Residue: | 1089 |
|---|
| Sequence: | MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP
MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY
VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG
TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN
EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK
EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL
TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL
VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD
RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII
SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG
SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL
LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY
VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN
LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA
RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM
VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK
SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII
PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS
SDLVEDSFL
|
|
|
|---|
| BDBM50501882 |
|---|
| n/a |
|---|
| Name | BDBM50501882 |
|---|
| Synonyms: | CHEMBL4446361 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H18FN5O2 |
|---|
| Mol. Mass. | 415.4197 |
|---|
| SMILES | Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
