| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase B-raf |
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| Ligand | BDBM50481997 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624869 (CHEMBL1104357) |
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| IC50 | 313±n/a nM |
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| Citation |  Suijkerbuijk, BM; Niculescu-Duvaz, I; Gaulon, C; Dijkstra, HP; Niculescu-Duvaz, D; Ménard, D; Zambon, A; Nourry, A; Davies, L; Manne, HA; Friedlos, F; Ogilvie, LM; Hedley, D; Lopes, F; Preece, NP; Moreno-Farre, J; Raynaud, FI; Kirk, R; Whittaker, S; Marais, R; Springer, CJ Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group. J Med Chem53:2741-56 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase B-raf |
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| Name: | Serine/threonine-protein kinase B-raf |
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| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 84446.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15056 |
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| Residue: | 766 |
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| Sequence: | MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEH
IEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTV
TSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDS
LKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRK
TFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPI
PQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQR
DRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSP
GPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDV
AVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHH
LHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATV
KSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNIN
NRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARS
LPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
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| BDBM50481997 |
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| n/a |
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| Name | BDBM50481997 |
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| Synonyms: | CHEMBL1090976 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H28FN7O3 |
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| Mol. Mass. | 565.5975 |
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| SMILES | Cn1c2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(F)cc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O |
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| Structure | 
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