Found 263 hits with Last Name = 'ogilvie' and Initial = 'lm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Carboxypeptidase G2
(Pseudomonas aeruginosa) | BDBM50171504
((S)-2-{4-[Bis-(2-chloro-ethyl)-amino]-2,3,5,6-tetr...)Show SMILES OC(=O)CC[C@H](NC(=O)c1c(F)c(F)c(N(CCCl)CCCl)c(F)c1F)C(O)=O Show InChI InChI=1S/C16H16Cl2F4N2O5/c17-3-5-24(6-4-18)14-12(21)10(19)9(11(20)13(14)22)15(27)23-7(16(28)29)1-2-8(25)26/h7H,1-6H2,(H,23,27)(H,25,26)(H,28,29)/t7-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.27E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against carboxypeptidase G2 from pseudomonas RS16 |
J Med Chem 48: 5321-8 (2005)
Article DOI: 10.1021/jm0502182
BindingDB Entry DOI: 10.7270/Q2DJ5F5C |
More data for this
Ligand-Target Pair | |
Carboxypeptidase G2
(Pseudomonas aeruginosa) | BDBM50171496
((S)-2-{4-[Bis-(2-iodo-ethyl)-amino]-2,3,5,6-tetraf...)Show SMILES OC(=O)CC[C@H](NC(=O)c1c(F)c(F)c(N(CCI)CCI)c(F)c1F)C(O)=O Show InChI InChI=1S/C16H16F4I2N2O5/c17-10-9(15(27)23-7(16(28)29)1-2-8(25)26)11(18)13(20)14(12(10)19)24(5-3-21)6-4-22/h7H,1-6H2,(H,23,27)(H,25,26)(H,28,29)/t7-/m0/s1 | KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.76E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibitory activity against carboxypeptidase G2 from pseudomonas RS16 |
J Med Chem 48: 5321-8 (2005)
Article DOI: 10.1021/jm0502182
BindingDB Entry DOI: 10.7270/Q2DJ5F5C |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482455
(CHEMBL1214001)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C23H17F4N5O3S/c1-11-21(33)32-20-19(29-11)17(7-8-28-20)35-13-4-6-15(18(10-13)36-2)30-22(34)31-16-9-12(23(25,26)27)3-5-14(16)24/h3-10H,1-2H3,(H,28,32,33)(H2,30,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482454
(CHEMBL1214000)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)ccc1NC(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C22H15F4N5O4S/c1-36-16-9-11(35-15-6-7-27-18-17(15)30-19(32)20(33)31-18)3-5-13(16)28-21(34)29-14-8-10(22(24,25)26)2-4-12(14)23/h2-9H,1H3,(H,30,32)(H,27,31,33)(H2,28,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482509
(CHEMBL1214614)Show SMILES Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C22H14F5N5O3/c1-10-20(33)32-19-18(29-10)17(6-7-28-19)35-12-3-5-15(14(24)9-12)30-21(34)31-16-8-11(22(25,26)27)2-4-13(16)23/h2-9H,1H3,(H,28,32,33)(H2,30,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482489
(CHEMBL1214055)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(nn1-c1ccccc1)C(C)(C)C Show InChI InChI=1S/C29H29N7O3S/c1-17-27(37)34-26-25(31-17)21(13-14-30-26)39-19-11-12-20(22(15-19)40-5)32-28(38)33-24-16-23(29(2,3)4)35-36(24)18-9-7-6-8-10-18/h6-16H,1-5H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482510
(CHEMBL1213998)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C22H15ClF3N5O4S/c1-36-16-9-11(35-15-6-7-27-18-17(15)30-19(32)20(33)31-18)3-5-14(16)29-21(34)28-10-2-4-13(23)12(8-10)22(24,25)26/h2-9H,1H3,(H,30,32)(H,27,31,33)(H2,28,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482488
(CHEMBL1213952)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C22H15ClF3N5O3S/c1-35-17-9-12(34-16-6-7-27-20-19(16)28-10-18(32)31-20)3-5-15(17)30-21(33)29-11-2-4-14(23)13(8-11)22(24,25)26/h2-10H,1H3,(H,27,31,32)(H2,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482490
(CHEMBL1214058)Show SMILES Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C26H17F4N5O3/c1-13-24(36)35-23-22(32-13)21(10-11-31-23)38-20-9-8-18(15-4-2-3-5-16(15)20)33-25(37)34-19-12-14(26(28,29)30)6-7-17(19)27/h2-12H,1H3,(H,31,35,36)(H2,33,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482482
(CHEMBL1214612)Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(F)(F)F Show InChI InChI=1S/C21H12F5N5O3/c22-12-3-1-10(21(24,25)26)7-15(12)30-20(33)29-14-4-2-11(8-13(14)23)34-16-5-6-27-19-18(16)28-9-17(32)31-19/h1-9H,(H,27,31,32)(H2,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482453
(CHEMBL1213999)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C22H15F4N5O3S/c1-35-17-9-12(34-16-6-7-27-20-19(16)28-10-18(32)31-20)3-5-14(17)29-21(33)30-15-8-11(22(24,25)26)2-4-13(15)23/h2-10H,1H3,(H,27,31,32)(H2,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482511
(CHEMBL1214056)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(nn1-c1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C29H29N7O3S/c1-17-6-8-18(9-7-17)36-24(15-23(35-36)29(2,3)4)33-28(38)32-20-11-10-19(14-22(20)40-5)39-21-12-13-30-27-26(21)31-16-25(37)34-27/h6-16H,1-5H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482514
(CHEMBL1213691)Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)c(=O)[nH]c23)cc1F)C(F)(F)F Show InChI InChI=1S/C21H12F5N5O4/c22-11-3-1-9(21(24,25)26)7-14(11)29-20(34)28-13-4-2-10(8-12(13)23)35-15-5-6-27-17-16(15)30-18(32)19(33)31-17/h1-8H,(H,30,32)(H,27,31,33)(H2,28,29,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142606
(US8933228, 8)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)c(C)nc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C33H31N7O3/c1-19-10-12-21(13-11-19)40-28(18-27(39-40)33(3,4)5)37-32(42)36-24-14-15-25(23-9-7-6-8-22(23)24)43-26-16-17-34-30-29(26)35-20(2)31(41)38-30/h6-18H,1-5H3,(H,34,38,41)(H2,36,37,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482512
(CHEMBL1214129)Show SMILES Nc1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C25H16F4N6O3/c26-15-6-5-12(25(27,28)29)11-17(15)33-24(37)32-16-7-8-18(14-4-2-1-3-13(14)16)38-19-9-10-31-22-20(19)34-21(30)23(36)35-22/h1-11H,(H2,30,34)(H,31,35,36)(H2,32,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482449
(CHEMBL1213824)Show SMILES Fc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C21H12ClF4N5O3/c22-13-3-1-10(7-12(13)21(24,25)26)29-20(33)30-15-4-2-11(8-14(15)23)34-16-5-6-27-19-18(16)28-9-17(32)31-19/h1-9H,(H,27,31,32)(H2,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482456
(CHEMBL1214057)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(nn1-c1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C30H31N7O3S/c1-17-7-9-19(10-8-17)37-25(16-24(36-37)30(3,4)5)34-29(39)33-21-12-11-20(15-23(21)41-6)40-22-13-14-31-27-26(22)32-18(2)28(38)35-27/h7-16H,1-6H3,(H,31,35,38)(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482508
(CHEMBL1214617)Show SMILES CC(C)(C)c1cccc(c1)C(=O)Nc1cccc(Oc2ccnc3[nH]c(=O)cnc23)c1 Show InChI InChI=1S/C24H22N4O3/c1-24(2,3)16-7-4-6-15(12-16)23(30)27-17-8-5-9-18(13-17)31-19-10-11-25-22-21(19)26-14-20(29)28-22/h4-14H,1-3H3,(H,27,30)(H,25,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482491
(CHEMBL1214133)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(N)nc34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H28N8O3/c1-31(2,3)24-17-25(39(38-24)18-9-5-4-6-10-18)35-30(41)34-21-13-14-22(20-12-8-7-11-19(20)21)42-23-15-16-33-28-26(23)36-27(32)29(40)37-28/h4-17H,1-3H3,(H2,32,36)(H,33,37,40)(H2,34,35,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482492
(CHEMBL1214136)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)c(N)nc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H30N8O3/c1-18-9-11-19(12-10-18)40-26(17-25(39-40)32(2,3)4)36-31(42)35-22-13-14-23(21-8-6-5-7-20(21)22)43-24-15-16-34-29-27(24)37-28(33)30(41)38-29/h5-17H,1-4H3,(H2,33,37)(H,34,38,41)(H2,35,36,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142605
(US8933228, 7)Show SMILES Cc1nc2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C32H29N7O3/c1-19-30(40)37-29-28(34-19)25(16-17-33-29)42-24-15-14-23(21-12-8-9-13-22(21)24)35-31(41)36-27-18-26(32(2,3)4)38-39(27)20-10-6-5-7-11-20/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142603
(US8933228, 5)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H27N7O3/c1-31(2,3)25-17-26(38(37-25)19-9-5-4-6-10-19)35-30(40)34-22-13-14-23(21-12-8-7-11-20(21)22)41-24-15-16-32-29-28(24)33-18-27(39)36-29/h4-18H,1-3H3,(H,32,36,39)(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142604
(US8933228, 6)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H29N7O3/c1-19-9-11-20(12-10-19)39-27(17-26(38-39)32(2,3)4)36-31(41)35-23-13-14-24(22-8-6-5-7-21(22)23)42-25-15-16-33-30-29(25)34-18-28(40)37-30/h5-18H,1-4H3,(H,33,37,40)(H2,35,36,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482476
(CHEMBL1214619)Show SMILES Cc1nc2c(Oc3cccc(NC(=O)c4cccc(c4)C(C)(C)C)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C25H24N4O3/c1-15-23(30)29-22-21(27-15)20(11-12-26-22)32-19-10-6-9-18(14-19)28-24(31)16-7-5-8-17(13-16)25(2,3)4/h5-14H,1-4H3,(H,28,31)(H,26,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482487
(CHEMBL1213886)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)c(N)nc23)cc1F)C(C)(C)C Show InChI InChI=1S/C28H27FN8O3/c1-15-5-7-16(8-6-15)37-22(14-21(36-37)28(2,3)4)33-27(39)32-19-10-9-17(13-18(19)29)40-20-11-12-31-25-23(20)34-24(30)26(38)35-25/h5-14H,1-4H3,(H2,30,34)(H,31,35,38)(H2,32,33,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482016
(CHEMBL1091432)Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C25H25N7O3/c1-25(2,3)19-13-20(32(4)31-19)28-23(33)27-16-9-10-17(15-8-6-5-7-14(15)16)35-18-11-12-26-22-21(18)29-24(34)30-22/h5-13H,1-4H3,(H2,27,28,33)(H2,26,29,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human BRAF V600E mutant expressed in baculovirus system |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482486
(CHEMBL1213821)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2)ccc1Cl Show InChI InChI=1S/C21H13ClF3N5O3/c22-15-6-3-12(9-14(15)21(23,24)25)29-20(32)28-11-1-4-13(5-2-11)33-16-7-8-26-19-18(16)27-10-17(31)30-19/h1-10H,(H,26,30,31)(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482468
(CHEMBL1214440)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3NC(=O)CNc23)cc1F)C(C)(C)C Show InChI InChI=1S/C28H28FN7O3/c1-16-5-7-17(8-6-16)36-23(14-22(35-36)28(2,3)4)33-27(38)32-20-10-9-18(13-19(20)29)39-21-11-12-30-26-25(21)31-15-24(37)34-26/h5-14,31H,15H2,1-4H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142599
(US8933228, 1)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H29N7O3/c1-18-9-11-19(12-10-18)38-26(17-25(37-38)31(2,3)4)34-29(39)33-22-13-14-23(21-8-6-5-7-20(21)22)41-24-15-16-32-28-27(24)35-30(40)36-28/h5-17H,1-4H3,(H2,33,34,39)(H2,32,35,36,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482484
(CHEMBL1212949)Show SMILES Fc1ccc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(S)nc23)cc1F)C(F)(F)F Show InChI InChI=1S/C20H12F5N5O2S/c21-11-3-1-9(20(23,24)25)7-14(11)28-18(31)27-13-4-2-10(8-12(13)22)32-15-5-6-26-17-16(15)29-19(33)30-17/h1-8H,(H2,27,28,31)(H2,26,29,30,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482450
(CHEMBL1213884)Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C Show InChI InChI=1S/C22H22FN7O3/c1-22(2,3)16-10-17(30(4)29-16)27-21(32)26-14-6-5-12(9-13(14)23)33-15-7-8-24-20-19(15)25-11-18(31)28-20/h5-11H,1-4H3,(H,24,28,31)(H2,26,27,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482511
(CHEMBL1214056)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)cnc23)ccc1NC(=O)Nc1cc(nn1-c1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C29H29N7O3S/c1-17-6-8-18(9-7-17)36-24(15-23(35-36)29(2,3)4)33-28(38)32-20-11-10-19(14-22(20)40-5)39-21-12-13-30-27-26(21)31-16-25(37)34-27/h6-16H,1-5H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482015
(CHEMBL1090977)Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C31H29N7O3/c1-31(2,3)25-18-26(38(36-25)19-10-6-5-7-11-19)34-29(39)33-22-14-15-23(21-13-9-8-12-20(21)22)41-24-16-17-32-28-27(24)37(4)30(40)35-28/h5-18H,1-4H3,(H,32,35,40)(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482489
(CHEMBL1214055)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(nn1-c1ccccc1)C(C)(C)C Show InChI InChI=1S/C29H29N7O3S/c1-17-27(37)34-26-25(31-17)21(13-14-30-26)39-19-11-12-20(22(15-19)40-5)32-28(38)33-24-16-23(29(2,3)4)35-36(24)18-9-7-6-8-10-18/h6-16H,1-5H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482448
(CHEMBL1213822)Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)c(=O)[nH]c34)cc2)ccc1Cl Show InChI InChI=1S/C21H13ClF3N5O4/c22-14-6-3-11(9-13(14)21(23,24)25)28-20(33)27-10-1-4-12(5-2-10)34-15-7-8-26-17-16(15)29-18(31)19(32)30-17/h1-9H,(H,29,31)(H,26,30,32)(H2,27,28,33) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482504
(CHEMBL1214563)Show SMILES FC(F)(F)Oc1cccc(c1)C(=O)Nc1cccc(Oc2ccnc3[nH]c(=O)cnc23)c1 Show InChI InChI=1S/C21H13F3N4O4/c22-21(23,24)32-15-6-1-3-12(9-15)20(30)27-13-4-2-5-14(10-13)31-16-7-8-25-19-18(16)26-11-17(29)28-19/h1-11H,(H,27,30)(H,25,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482519
(CHEMBL1214616)Show SMILES Oc1nc2c(Oc3cccc(NC(=O)c4cccc(OC(F)(F)F)c4)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C21H13F3N4O5/c22-21(23,24)33-14-6-1-3-11(9-14)18(29)26-12-4-2-5-13(10-12)32-15-7-8-25-17-16(15)27-19(30)20(31)28-17/h1-10H,(H,26,29)(H,27,30)(H,25,28,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482451
(CHEMBL1213951)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C Show InChI InChI=1S/C28H26FN7O3/c1-16-5-7-17(8-6-16)36-23(14-22(35-36)28(2,3)4)33-27(38)32-20-10-9-18(13-19(20)29)39-21-11-12-30-26-25(21)31-15-24(37)34-26/h5-15H,1-4H3,(H,30,34,37)(H2,32,33,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482456
(CHEMBL1214057)Show SMILES CSc1cc(Oc2ccnc3[nH]c(=O)c(C)nc23)ccc1NC(=O)Nc1cc(nn1-c1ccc(C)cc1)C(C)(C)C Show InChI InChI=1S/C30H31N7O3S/c1-17-7-9-19(10-8-17)37-25(16-24(36-37)30(3,4)5)34-29(39)33-21-12-11-20(15-23(21)41-6)40-22-13-14-31-27-26(22)32-18(2)28(38)35-27/h7-16H,1-6H3,(H,31,35,38)(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482485
(CHEMBL1213754)Show SMILES CN(C)c1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]1 Show InChI InChI=1S/C22H17F5N6O2/c1-33(2)20-31-18-17(7-8-28-19(18)32-20)35-12-4-6-15(14(24)10-12)29-21(34)30-16-9-11(22(25,26)27)3-5-13(16)23/h3-10H,1-2H3,(H,28,31,32)(H2,29,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142601
(US8933228, 3)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H31N7O3/c1-19-10-12-20(13-11-19)39-27(18-26(37-39)32(2,3)4)35-30(40)34-23-14-15-24(22-9-7-6-8-21(22)23)42-25-16-17-33-29-28(25)38(5)31(41)36-29/h6-18H,1-5H3,(H,33,36,41)(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482014
(CHEMBL1090980)Show SMILES Cn1c2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccccc4)C(C)(C)C)c4ccccc34)c2[nH]c1=O Show InChI InChI=1S/C31H29N7O3/c1-31(2,3)25-18-26(38(36-25)19-10-6-5-7-11-19)34-29(39)33-22-14-15-23(21-13-9-8-12-20(21)22)41-24-16-17-32-28-27(24)35-30(40)37(28)4/h5-18H,1-4H3,(H,35,40)(H2,33,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482444
(CHEMBL1213689)Show SMILES Nc1nc2c(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)c(F)c3)ccnc2[nH]c1=O Show InChI InChI=1S/C21H13F5N6O3/c22-11-3-1-9(21(24,25)26)7-14(11)30-20(34)29-13-4-2-10(8-12(13)23)35-15-5-6-28-18-16(15)31-17(27)19(33)32-18/h1-8H,(H2,27,31)(H,28,32,33)(H2,29,30,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482021
(CHEMBL1089706)Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1)C(C)(C)C Show InChI InChI=1S/C21H23N7O3/c1-21(2,3)15-11-16(28(4)27-15)24-19(29)23-12-5-7-13(8-6-12)31-14-9-10-22-18-17(14)25-20(30)26-18/h5-11H,1-4H3,(H2,23,24,29)(H2,22,25,26,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of human BRAF V600E mutant expressed in baculovirus system |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482475
(CHEMBL1214618)Show SMILES CC(C)(C)c1cccc(c1)C(=O)Nc1cccc(Oc2ccnc3ncc(=O)[nH]c23)c1 Show InChI InChI=1S/C24H22N4O3/c1-24(2,3)16-7-4-6-15(12-16)23(30)27-17-8-5-9-18(13-17)31-19-10-11-25-22-21(19)28-20(29)14-26-22/h4-14H,1-3H3,(H,27,30)(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of B-Raf V600E mutant |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM142600
(US8933228, 2)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C30H27N7O3/c1-30(2,3)24-17-25(37(36-24)18-9-5-4-6-10-18)33-28(38)32-21-13-14-22(20-12-8-7-11-19(20)21)40-23-15-16-31-27-26(23)34-29(39)35-27/h4-17H,1-3H3,(H2,32,33,38)(H2,31,34,35,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50481997
(CHEMBL1090976)Show SMILES Cn1c2c(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(F)cc4)C(C)(C)C)c4ccccc34)ccnc2[nH]c1=O Show InChI InChI=1S/C31H28FN7O3/c1-31(2,3)25-17-26(39(37-25)19-11-9-18(32)10-12-19)35-29(40)34-22-13-14-23(21-8-6-5-7-20(21)22)42-24-15-16-33-28-27(24)38(4)30(41)36-28/h5-17H,1-4H3,(H,33,36,41)(H2,34,35,40) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482518
(CHEMBL1214382)Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4nc(N)c(=O)[nH]c34)c3ccccc23)n(n1)-c1ccccc1 Show InChI InChI=1S/C31H28N8O3/c1-31(2,3)24-17-25(39(38-24)18-9-5-4-6-10-18)35-30(41)34-21-13-14-22(20-12-8-7-11-19(20)21)42-23-15-16-33-28-26(23)36-29(40)27(32)37-28/h4-17H,1-3H3,(H,36,40)(H2,32,33,37)(H2,34,35,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant-mediated ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 5639-55 (2010)
Article DOI: 10.1021/jm100383b
BindingDB Entry DOI: 10.7270/Q22V2JZS |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482017
(CHEMBL1091430)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3n(C)c(=O)[nH]c23)cc1)C(C)(C)C Show InChI InChI=1S/C28H29N7O3/c1-17-6-10-19(11-7-17)35-23(16-22(33-35)28(2,3)4)31-26(36)30-18-8-12-20(13-9-18)38-21-14-15-29-25-24(21)32-27(37)34(25)5/h6-16H,1-5H3,(H,32,37)(H2,30,31,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50482013
(CHEMBL1091849)Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)[nH]c23)cc1F)C(C)(C)C Show InChI InChI=1S/C27H26FN7O3/c1-15-5-7-16(8-6-15)35-22(14-21(34-35)27(2,3)4)31-25(36)30-19-10-9-17(13-18(19)28)38-20-11-12-29-24-23(20)32-26(37)33-24/h5-14H,1-4H3,(H2,30,31,36)(H2,29,32,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research
Curated by ChEMBL
| Assay Description
Inhibition of BRAF V600E mutant ERK phosphorylation in human WM266.4 cells |
J Med Chem 53: 2741-56 (2010)
Article DOI: 10.1021/jm900607f
BindingDB Entry DOI: 10.7270/Q2WD43CH |
More data for this
Ligand-Target Pair | |
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