| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase |
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| Ligand | BDBM50485255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_823533 (CHEMBL2045976) |
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| IC50 | 12±n/a nM |
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| Citation |  Wang, X; Zhang, J; Huang, Y; Wang, R; Zhang, L; Qiao, K; Li, L; Liu, C; Ouyang, Y; Xu, W; Zhang, Z; Zhang, L; Shao, Y; Jiang, S; Ma, L; Liu, J Design, synthesis, and biological evaluation of 1-[(2-benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as potent HIV-1 non-nucleoside reverse transcriptase inhibitors with an improved drug resistance profile. J Med Chem55:2242-50 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase |
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| Name: | Reverse transcriptase |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 29598.37 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WKE8 |
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| Residue: | 254 |
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| Sequence: | PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVF
AIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLD
KDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIY
QYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVN
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| BDBM50485255 |
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| n/a |
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| Name | BDBM50485255 |
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| Synonyms: | CHEMBL2041791 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N3O3 |
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| Mol. Mass. | 365.4256 |
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| SMILES | CN(C)c1c(Cc2ccccc2)n(COCc2ccccc2)c(=O)[nH]c1=O |
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| Structure | 
|
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