Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50049730 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_877418 (CHEMBL2182848) |
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IC50 | 170±n/a nM |
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Citation | Sartini, S; Cosconati, S; Marinelli, L; Barresi, E; Di Maro, S; Simorini, F; Taliani, S; Salerno, S; Marini, AM; Da Settimo, F; Novellino, E; La Motta, C Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies. J Med Chem55:10523-31 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
Type: | PROTEIN |
Mol. Mass.: | 35797.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1512484 |
Residue: | 316 |
Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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BDBM50049730 |
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n/a |
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Name | BDBM50049730 |
Synonyms: | 2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL56337 | Epalrestat | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C15H13NO3S2 |
Mol. Mass. | 319.399 |
SMILES | C\C(\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1 |
Structure |
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