| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 2 |
|---|
| Ligand | BDBM50495226 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1286093 (CHEMBL3106691) |
|---|
| IC50 | 190±n/a nM |
|---|
| Citation |  Irannejad, H; Kebriaieezadeh, A; Zarghi, A; Montazer-Sadegh, F; Shafiee, A; Assadieskandar, A; Amini, M Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors. Bioorg Med Chem22:865-73 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Prostaglandin G/H synthase 2 |
|---|
| Name: | Prostaglandin G/H synthase 2 |
|---|
| Synonyms: | COX2 | Cyclooxygenase-1 (COX-1) | Cyclooxygenase-2 (COX-2) | PGH2_SHEEP | PTGS2 | Prostaglandin G/H synthase (Cyclooxygenase-2) | Prostaglandin G/H synthase (cyclooxygenase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68976.98 |
|---|
| Organism: | Ovis aries (Sheep) |
|---|
| Description: | n/a |
|---|
| Residue: | 603 |
|---|
| Sequence: | MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLT
RIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYS
YKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTN
LMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQ
MINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDV
LKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQN
RIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVA
GRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALY
GDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVG
FKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERS
TEL
|
|
|
|---|
| BDBM50495226 |
|---|
| n/a |
|---|
| Name | BDBM50495226 |
|---|
| Synonyms: | CHEMBL3103783 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O2S2 |
|---|
| Mol. Mass. | 357.45 |
|---|
| SMILES | CSc1nnc(-c2ccc(cc2)S(C)(=O)=O)c(n1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
