Found 180 hits with Last Name = 'zarghi' and Initial = 'a' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300865
(7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)be...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2ccc3CCCCc3c2n1 Show InChI InChI=1S/C21H19NO4S/c1-27(25,26)15-9-6-14(7-10-15)19-12-18(21(23)24)17-11-8-13-4-2-3-5-16(13)20(17)22-19/h6-12H,2-5H2,1H3,(H,23,24) | PDB
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| CHEMBL
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50143486
(CHEMBL366422 | N-Acetyl-4-[4-(4-methanesulfonyl-ph...)Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccc(cc1)S(C)(=O)=O |t:14| Show InChI InChI=1S/C19H17NO7S2/c1-12(21)20-29(25,26)16-9-3-13(4-10-16)17-11-27-19(22)18(17)14-5-7-15(8-6-14)28(2,23)24/h3-10H,11H2,1-2H3,(H,20,21) | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Alberta
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity of the compound against prostaglandin G/H synthase 2 from ovine |
Bioorg Med Chem Lett 14: 1957-60 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.076
BindingDB Entry DOI: 10.7270/Q20P0ZFX |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50295359
(3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1Sc2ccccc2C(=O)N1c1ccc(F)cc1 Show InChI InChI=1S/C21H16FNO3S2/c1-28(25,26)17-12-6-14(7-13-17)21-23(16-10-8-15(22)9-11-16)20(24)18-4-2-3-5-19(18)27-21/h2-13,21H,1H3 | PDB
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| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300866
(2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-ca...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2ccc3ccccc3c2n1 Show InChI InChI=1S/C21H15NO4S/c1-27(25,26)15-9-6-14(7-10-15)19-12-18(21(23)24)17-11-8-13-4-2-3-5-16(13)20(17)22-19/h2-12H,1H3,(H,23,24) | PDB
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| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326830
(2-(4-azido)phenyl)-8-benzoyl-quinoline-4-carboxyli...)Show SMILES OC(=O)c1cc(nc2c(cccc12)C(=O)c1ccccc1)-c1ccc(cc1)N=[N+]=[N-] Show InChI InChI=1S/C23H14N4O3/c24-27-26-16-11-9-14(10-12-16)20-13-19(23(29)30)17-7-4-8-18(21(17)25-20)22(28)15-5-2-1-3-6-15/h1-13H,(H,29,30) | PDB
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| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University
| Assay Description
The ability of the test compounds to inhibit ovine COX-1 and COX-2 was determined using chemiluminescent enzyme assays kit according to our previousl... |
Med Chem Res 19: 782-793 (2009)
BindingDB Entry DOI: 10.7270/Q2T72G2X |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50295358
(3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-...)Show SMILES Cc1ccc(cc1)N1C(Sc2ccccc2C1=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C22H19NO3S2/c1-15-7-11-17(12-8-15)23-21(24)19-5-3-4-6-20(19)27-22(23)16-9-13-18(14-10-16)28(2,25)26/h3-14,22H,1-2H3 | PDB
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Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Homo sapiens (Human)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of COX2 |
Bioorg Med Chem Lett 17: 5634-7 (2007)
Article DOI: 10.1016/j.bmcl.2007.07.084
BindingDB Entry DOI: 10.7270/Q22807BC |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50346138
(3-benzyl-2-(4-(methylsulfonyl)phenyl)-1,3-thiazina...)Show InChI InChI=1S/C18H19NO3S2/c1-24(21,22)16-9-7-15(8-10-16)18-19(17(20)11-12-23-18)13-14-5-3-2-4-6-14/h2-10,18H,11-13H2,1H3 | PDB
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Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Eur J Med Chem 45: 4013-7 (2010)
Article DOI: 10.1016/j.ejmech.2010.05.058
BindingDB Entry DOI: 10.7270/Q2G1612W |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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TBA
| Assay Description
Inhibition of Ovine COX-2 by chemiluminescent enzyme method |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115960
BindingDB Entry DOI: 10.7270/Q2SX6HVR |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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Mazandaran University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 using arachidonic acid as substrate by chemiluminescence assay |
Bioorg Med Chem 22: 865-73 (2014)
Article DOI: 10.1016/j.bmc.2013.12.002
BindingDB Entry DOI: 10.7270/Q2319ZV3 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 18: 1336-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.021
BindingDB Entry DOI: 10.7270/Q2Z89C4T |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM11639
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25) | PDB
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Shahid Beheshti University MC
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay |
Bioorg Med Chem 18: 1029-33 (2010)
Article DOI: 10.1016/j.bmc.2009.12.060
BindingDB Entry DOI: 10.7270/Q2V40V94 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326828
(8-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2cccc(C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C24H17NO5S/c1-31(29,30)17-12-10-15(11-13-17)21-14-20(24(27)28)18-8-5-9-19(22(18)25-21)23(26)16-6-3-2-4-7-16/h2-14H,1H3,(H,27,28) | PDB
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| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50326309
((Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-...)Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)C(=C/c1ccccc1)\c1ccccc1 Show InChI InChI=1S/C22H18O3S/c1-26(24,25)20-14-12-19(13-15-20)22(23)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-16H,1H3/b21-16- | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Eur J Med Chem 45: 4013-7 (2010)
Article DOI: 10.1016/j.ejmech.2010.05.058
BindingDB Entry DOI: 10.7270/Q2G1612W |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50552661
(CHEMBL4759813)Show SMILES COc1ccc(cc1OC)C1=NOC2(Cc3ccccc3C2=O)C1c1ccc(cc1)S(C)(=O)=O |t:11| | PDB
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TBA
| Assay Description
Inhibition of Ovine COX-2 by chemiluminescent enzyme method |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115960
BindingDB Entry DOI: 10.7270/Q2SX6HVR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50326318
((E/Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyr...)Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)C(=Cc1ccncc1)c1ccccc1 |w:13.14| Show InChI InChI=1S/C21H17NO3S/c1-26(24,25)19-9-7-18(8-10-19)21(23)20(17-5-3-2-4-6-17)15-16-11-13-22-14-12-16/h2-15H,1H3 | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Eur J Med Chem 45: 4013-7 (2010)
Article DOI: 10.1016/j.ejmech.2010.05.058
BindingDB Entry DOI: 10.7270/Q2G1612W |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50346139
(2-(4-(methylsulfonyl)phenyl)-3-phenethyl-1,3-thiaz...)Show InChI InChI=1S/C19H21NO3S2/c1-25(22,23)17-9-7-16(8-10-17)19-20(18(21)12-14-24-19)13-11-15-5-3-2-4-6-15/h2-10,19H,11-14H2,1H3 | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50295356
(3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazi...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1Sc2ccccc2C(=O)N1Cc1ccccc1 Show InChI InChI=1S/C22H19NO3S2/c1-28(25,26)18-13-11-17(12-14-18)22-23(15-16-7-3-2-4-8-16)21(24)19-9-5-6-10-20(19)27-22/h2-14,22H,15H2,1H3 | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50306357
(2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-c...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2ccccc2c(C(O)=O)c1-c1ccccc1 Show InChI InChI=1S/C23H17NO4S/c1-29(27,28)17-13-11-16(12-14-17)22-20(15-7-3-2-4-8-15)21(23(25)26)18-9-5-6-10-19(18)24-22/h2-14H,1H3,(H,25,26) | PDB
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| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University MC
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay |
Bioorg Med Chem 18: 1029-33 (2010)
Article DOI: 10.1016/j.bmc.2009.12.060
BindingDB Entry DOI: 10.7270/Q2V40V94 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300867
(2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2cccc(-c3ccccc3)c2n1 Show InChI InChI=1S/C23H17NO4S/c1-29(27,28)17-12-10-16(11-13-17)21-14-20(23(25)26)19-9-5-8-18(22(19)24-21)15-6-3-2-4-7-15/h2-14H,1H3,(H,25,26) | PDB
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| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300868
(7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline...)Show SMILES Cc1ccc2c(cc(nc2c1C)-c1ccc(cc1)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C19H17NO4S/c1-11-4-9-15-16(19(21)22)10-17(20-18(15)12(11)2)13-5-7-14(8-6-13)25(3,23)24/h4-10H,1-3H3,(H,21,22) | PDB
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| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326831
(2-(4-azido)phenyl)-6-benzoyl-quinoline-4-carboxyli...)Show SMILES OC(=O)c1cc(nc2ccc(cc12)C(=O)c1ccccc1)-c1ccc(cc1)N=[N+]=[N-] Show InChI InChI=1S/C23H14N4O3/c24-27-26-17-9-6-14(7-10-17)21-13-19(23(29)30)18-12-16(8-11-20(18)25-21)22(28)15-4-2-1-3-5-15/h1-13H,(H,29,30) | PDB
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Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326829
(6-benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2cc(ccc2n1)C(=O)c1ccccc1 Show InChI InChI=1S/C24H17NO5S/c1-31(29,30)18-10-7-15(8-11-18)22-14-20(24(27)28)19-13-17(9-12-21(19)25-22)23(26)16-5-3-2-4-6-16/h2-14H,1H3,(H,27,28) | PDB
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| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50326316
((E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)pheny...)Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)C(=C\c1ccc(O)cc1)\c1ccccc1 Show InChI InChI=1S/C22H18O4S/c1-27(25,26)20-13-9-18(10-14-20)22(24)21(17-5-3-2-4-6-17)15-16-7-11-19(23)12-8-16/h2-15,23H,1H3/b21-15+ | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Eur J Med Chem 45: 4013-7 (2010)
Article DOI: 10.1016/j.ejmech.2010.05.058
BindingDB Entry DOI: 10.7270/Q2G1612W |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300864
(5-methoxy-2-(4-(methylsulfonyl)phenyl)-1H-indole |...)Show InChI InChI=1S/C16H15NO3S/c1-20-13-5-8-15-12(9-13)10-16(17-15)11-3-6-14(7-4-11)21(2,18)19/h3-10,17H,1-2H3 | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50306356
(4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquino...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2ccccc2c(N)c1-c1ccccc1 Show InChI InChI=1S/C22H18N2O2S/c1-27(25,26)17-13-11-16(12-14-17)22-20(15-7-3-2-4-8-15)21(23)18-9-5-6-10-19(18)24-22/h2-14H,1H3,(H2,23,24) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University MC
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay |
Bioorg Med Chem 18: 1029-33 (2010)
Article DOI: 10.1016/j.bmc.2009.12.060
BindingDB Entry DOI: 10.7270/Q2V40V94 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50295361
(2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthi...)Show SMILES CS(=O)(=O)c1ccc(cc1)C1Sc2ccccc2C(=O)N1CCc1ccccc1 Show InChI InChI=1S/C23H21NO3S2/c1-29(26,27)19-13-11-18(12-14-19)23-24(16-15-17-7-3-2-4-8-17)22(25)20-9-5-6-10-21(20)28-23/h2-14,23H,15-16H2,1H3 | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326826
(2-(4-acetamido)phenyl)-8-benzoyl-quinoline-4-carbo...)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(C(O)=O)c2cccc(C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C25H18N2O4/c1-15(28)26-18-12-10-16(11-13-18)22-14-21(25(30)31)19-8-5-9-20(23(19)27-22)24(29)17-6-3-2-4-7-17/h2-14H,1H3,(H,26,28)(H,30,31) | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50346142
(2-(4-(methylsulfonyl)phenyl)-3-pentyl-1,3-thiazina...)Show InChI InChI=1S/C16H23NO3S2/c1-3-4-5-11-17-15(18)10-12-21-16(17)13-6-8-14(9-7-13)22(2,19)20/h6-9,16H,3-5,10-12H2,1-2H3 | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50346141
(3-butyl-2-(4-(methylsulfonyl)phenyl)-1,3-thiazinan...)Show InChI InChI=1S/C15H21NO3S2/c1-3-4-10-16-14(17)9-11-20-15(16)12-5-7-13(8-6-12)21(2,18)19/h5-8,15H,3-4,9-11H2,1-2H3 | PDB
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| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50326827
(2-(4-acetamido)phenyl)-6-benzoyl-quinoline-4-carbo...)Show SMILES CC(=O)Nc1ccc(cc1)-c1cc(C(O)=O)c2cc(ccc2n1)C(=O)c1ccccc1 Show InChI InChI=1S/C25H18N2O4/c1-15(28)26-19-10-7-16(8-11-19)23-14-21(25(30)31)20-13-18(9-12-22(20)27-23)24(29)17-5-3-2-4-6-17/h2-14H,1H3,(H,26,28)(H,30,31) | PDB
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| n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300869
(8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-c...)Show SMILES Cc1cccc2c(cc(nc12)-c1ccc(cc1)S(C)(=O)=O)C(O)=O Show InChI InChI=1S/C18H15NO4S/c1-11-4-3-5-14-15(18(20)21)10-16(19-17(11)14)12-6-8-13(9-7-12)24(2,22)23/h3-10H,1-2H3,(H,20,21) | PDB
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| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50552662
(CHEMBL4781751)Show SMILES COc1cc(cc(OC)c1OC)C1=NOC2(Cc3ccccc3C2=O)C1c1ccc(cc1)S(C)(=O)=O |t:13| | PDB
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TBA
| Assay Description
Inhibition of Ovine COX-2 by chemiluminescent enzyme method |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115960
BindingDB Entry DOI: 10.7270/Q2SX6HVR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50300870
(2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxyli...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C17H13NO4S/c1-23(21,22)12-8-6-11(7-9-12)16-10-14(17(19)20)13-4-2-3-5-15(13)18-16/h2-10H,1H3,(H,19,20) | PDB
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| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent enzyme assay |
Bioorg Med Chem 17: 5312-7 (2009)
Article DOI: 10.1016/j.bmc.2009.05.084
BindingDB Entry DOI: 10.7270/Q2NS0TZX |
More data for this
Ligand-Target Pair | |
Cytochrome c oxidase subunit 2
(Ovis aries) | BDBM50300870
(2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxyli...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cc(C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C17H13NO4S/c1-23(21,22)12-8-6-11(7-9-12)16-10-14(17(19)20)13-4-2-3-5-15(13)18-16/h2-10H,1H3,(H,19,20) | PDB
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Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of sheep COX2 |
Bioorg Med Chem 18: 5855-60 (2010)
Article DOI: 10.1016/j.bmc.2010.06.094
BindingDB Entry DOI: 10.7270/Q23J3D6V |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50495225
(CHEMBL3103780)Show SMILES CSc1nnc(-c2ccc(cc2)S(C)(=O)=O)c(n1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C17H14ClN3O2S2/c1-24-17-19-15(11-3-7-13(18)8-4-11)16(20-21-17)12-5-9-14(10-6-12)25(2,22)23/h3-10H,1-2H3 | PDB
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Mazandaran University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 using arachidonic acid as substrate by chemiluminescence assay |
Bioorg Med Chem 22: 865-73 (2014)
Article DOI: 10.1016/j.bmc.2013.12.002
BindingDB Entry DOI: 10.7270/Q2319ZV3 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50552657
(CHEMBL4794538)Show SMILES CS(=O)(=O)c1ccc(cc1)C1C(=NOC11Cc2ccccc2C1=O)c1ccc(F)cc1 |c:12| | PDB
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TBA
| Assay Description
Inhibition of Ovine COX-2 by chemiluminescent enzyme method |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115960
BindingDB Entry DOI: 10.7270/Q2SX6HVR |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50295357
(3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3...)Show SMILES COc1ccc(cc1)N1C(Sc2ccccc2C1=O)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C22H19NO4S2/c1-27-17-11-9-16(10-12-17)23-21(24)19-5-3-4-6-20(19)28-22(23)15-7-13-18(14-8-15)29(2,25)26/h3-14,22H,1-2H3 | PDB
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Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Bioorg Med Chem 17: 5369-73 (2009)
Article DOI: 10.1016/j.bmc.2009.06.056
BindingDB Entry DOI: 10.7270/Q2XS5VDJ |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50346140
(2-(4-(methylsulfonyl)phenyl)-3-propyl-1,3-thiazina...)Show InChI InChI=1S/C14H19NO3S2/c1-3-9-15-13(16)8-10-19-14(15)11-4-6-12(7-5-11)20(2,17)18/h4-7,14H,3,8-10H2,1-2H3 | PDB
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Shahid Beheshti University (M.C)
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 19: 3162-5 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.125
BindingDB Entry DOI: 10.7270/Q2XG9RGM |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50306354
(4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquino...)Show SMILES Cc1c(-c2ccccc2)c(nc2ccccc12)-c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C23H19NO2S/c1-16-20-10-6-7-11-21(20)24-23(22(16)17-8-4-3-5-9-17)18-12-14-19(15-13-18)27(2,25)26/h3-15H,1-2H3 | PDB
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Shahid Beheshti University MC
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay |
Bioorg Med Chem 18: 1029-33 (2010)
Article DOI: 10.1016/j.bmc.2009.12.060
BindingDB Entry DOI: 10.7270/Q2V40V94 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50233180
(1-(4-methoxyphenyl)-3-(4-(methylsulfonyl)phenyl)ur...)Show InChI InChI=1S/C15H16N2O4S/c1-21-13-7-3-11(4-8-13)16-15(18)17-12-5-9-14(10-6-12)22(2,19)20/h3-10H,1-2H3,(H2,16,17,18) | PDB
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Shaheed Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescent assay |
Bioorg Med Chem Lett 18: 1336-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.01.021
BindingDB Entry DOI: 10.7270/Q2Z89C4T |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50306353
(2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline | C...)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1nc2ccccc2cc1-c1ccccc1 Show InChI InChI=1S/C22H17NO2S/c1-26(24,25)19-13-11-17(12-14-19)22-20(16-7-3-2-4-8-16)15-18-9-5-6-10-21(18)23-22/h2-15H,1H3 | PDB
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Shahid Beheshti University MC
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay |
Bioorg Med Chem 18: 1029-33 (2010)
Article DOI: 10.1016/j.bmc.2009.12.060
BindingDB Entry DOI: 10.7270/Q2V40V94 |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50326308
((E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-...)Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)C(=C\c1ccccc1)\c1ccccc1 Show InChI InChI=1S/C22H18O3S/c1-26(24,25)20-14-12-19(13-15-20)22(23)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-16H,1H3/b21-16+ | PDB
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Shahid Beheshti University of Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of ovine COX2 by chemiluminescence assay |
Eur J Med Chem 45: 4013-7 (2010)
Article DOI: 10.1016/j.ejmech.2010.05.058
BindingDB Entry DOI: 10.7270/Q2G1612W |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Ovis aries (Sheep)) | BDBM50552660
(CHEMBL4762017)Show SMILES COc1ccc(cc1)C1=NOC2(Cc3ccccc3C2=O)C1c1ccc(cc1)S(C)(=O)=O |t:9| | PDB
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TBA
| Assay Description
Inhibition of Ovine COX-2 by chemiluminescent enzyme method |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115960
BindingDB Entry DOI: 10.7270/Q2SX6HVR |
More data for this
Ligand-Target Pair | |
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