| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50499502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1541406 (CHEMBL3743381) |
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| IC50 | 9.0±n/a nM |
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| Citation |  Lopez-Tapia, F; Walker, KA; Brotherton-Pleiss, C; Caroon, J; Nitzan, D; Lowrie, L; Gleason, S; Zhao, SH; Berger, J; Cockayne, D; Phippard, D; Suttmann, R; Fitch, WL; Bourdet, D; Rege, P; Huang, X; Broadbent, S; Dvorak, C; Zhu, J; Wagner, P; Padilla, F; Loe, B; Jahangir, A; Alker, A Novel Series of Dihydropyridinone P2X7 Receptor Antagonists. J Med Chem58:8413-26 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50499502 |
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| n/a |
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| Name | BDBM50499502 |
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| Synonyms: | CHEMBL3740237 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18BrFN2O4 |
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| Mol. Mass. | 449.27 |
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| SMILES | COc1cc(Br)c(NC(=O)C2=CNC(=O)C[C@H]2c2cccc(F)c2)cc1OC |r,t:10| |
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| Structure | 
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