| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, NMDA 1 |
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| Ligand | BDBM50008757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_140403 (CHEMBL746729) |
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| IC50 | 280±n/a nM |
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| Citation |  Cai, SX; Zhou, ZL; Huang, JC; Whittemore, ER; Egbuwoku, ZO; Lü, Y; Hawkinson, JE; Woodward, RM; Weber, E; Keana, JF Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site. J Med Chem39:3248-55 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, NMDA 1 |
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| Name: | Glutamate receptor ionotropic, NMDA 1 |
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| Synonyms: | Glutamate (NMDA) receptor subunit zeta 1 | Glutamate [NMDA] receptor subunit zeta-1 | Glutamate-NMDA-Channel | Glutamate-NMDA-MK801 | Glutamate-NMDA-Polyamine | Grin1 | NMDA | NMDZ1_RAT | Nmdar1 | phencyclidine |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105533.40 |
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| Organism: | RAT |
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| Description: | P35439 |
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| Residue: | 938 |
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| Sequence: | MSTMHLLTFALLFSCSFARAACDPKIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQL
NATSVTHKPNAIQMALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLG
LTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRL
ETLLEERESKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAAAMLNM
TGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAVGVVAQAVHELLEKEN
ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRK
LVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTC
KEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVA
DGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTI
LVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDA
LTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRP
EERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQA
VRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSH
ENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFMLVAGGIVAGIFLIFIEIAYKRH
KDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDT
STGGGRGALQNQKDTVLPRRAIEREEGQLQLCSRHRES
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| BDBM50008757 |
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| n/a |
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| Name | BDBM50008757 |
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| Synonyms: | 5,7-Dichloro-1,4-dihydro-quinoxaline-2,3-dione | CHEMBL282003 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H4Cl2N2O2 |
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| Mol. Mass. | 231.036 |
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| SMILES | Clc1cc(Cl)c2[nH]c(=O)c(=O)[nH]c2c1 |
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| Structure | 
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