| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 2,3-dioxygenase |
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| Ligand | BDBM50511733 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1845469 (CHEMBL4345896) |
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| IC50 | 60±n/a nM |
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| Citation |  Parr, BT; Pastor, R; Sellers, BD; Pei, Z; Jaipuri, FA; Castanedo, GM; Gazzard, L; Kumar, S; Li, X; Liu, W; Mendonca, R; Pavana, RK; Potturi, H; Shao, C; Velvadapu, V; Waldo, JP; Wu, G; Yuen, PW; Zhang, Z; Zhang, Y; Harris, SF; Oh, AJ; DiPasquale, A; Dement, K; La, H; Goon, L; Gustafson, A; VanderPorten, EC; Mautino, MR; Liu, Y Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors. ACS Med Chem Lett11:541-549 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 2,3-dioxygenase |
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| Name: | Tryptophan 2,3-dioxygenase |
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| Synonyms: | T23O_HUMAN | TDO | TDO2 | TO | TRPO | Tryptamin 2,3-dioxygenase | Tryptophan oxygenase | Tryptophan pyrrolase | Tryptophanase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47874.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_825691 |
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| Residue: | 406 |
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| Sequence: | MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSE
TKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSV
ILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHY
RDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIR
IQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYRE
EPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYK
VFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
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| BDBM50511733 |
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| n/a |
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| Name | BDBM50511733 |
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| Synonyms: | CHEMBL4443553 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N2O |
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| Mol. Mass. | 200.2365 |
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| SMILES | OCCC1c2cncn2-c2ccccc12 |
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| Structure | 
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