| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein Mdm4 |
|---|
| Ligand | BDBM143333 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1852379 (CHEMBL4353003) |
|---|
| IC50 | 4160±n/a nM |
|---|
| Citation |  Liu, Y; Wang, X; Wang, G; Yang, Y; Yuan, Y; Ouyang, L The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy. Eur J Med Chem176:92-104 (2019) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein Mdm4 |
|---|
| Name: | Protein Mdm4 |
|---|
| Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 |
|---|
| Type: | Oncoprotein |
|---|
| Mol. Mass.: | 54842.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. |
|---|
| Residue: | 490 |
|---|
| Sequence: | MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYI
MVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTL
ALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQ
DETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWF
LNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTS
EDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVP
DCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQ
RTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKE
IQLVIKVFIA
|
|
|
|---|
| BDBM143333 |
|---|
| n/a |
|---|
| Name | BDBM143333 |
|---|
| Synonyms: | US8969341, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H23Cl2FN4O |
|---|
| Mol. Mass. | 509.402 |
|---|
| SMILES | CC(C)c1c2C(N(C(=O)c2nn1Cc1ccccn1)c1cccc(Cl)c1F)c1ccc(Cl)cc1C |
|---|
| Structure | 
|
|---|
Search and Browse
