| Reaction Details |
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 | Report a problem with these data |
| Target | Toll-like receptor 7 |
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| Ligand | BDBM50514141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1855694 (CHEMBL4356423) |
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| IC50 | >20000±n/a nM |
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| Citation |  Padilla-Salinas, R; Anderson, R; Sakaniwa, K; Zhang, S; Nordeen, P; Lu, C; Shimizu, T; Yin, H Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors J Med Chem62:10221-10244 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Toll-like receptor 7 |
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| Name: | Toll-like receptor 7 |
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| Synonyms: | ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7) |
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| Type: | Enzyme |
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| Mol. Mass.: | 120945.35 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYK1 |
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| Residue: | 1049 |
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| Sequence: | MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIP
GGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKP
RSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLG
QNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKI
QEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSN
SLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASM
NLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQF
KRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNK
EASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQP
LAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQK
LMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKN
SLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSN
CSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLL
HHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNL
ILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTK
DPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDK
YAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQ
AHPYFWQCLKNALATDNHVAYSQVFKETV
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| BDBM50514141 |
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| n/a |
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| Name | BDBM50514141 |
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| Synonyms: | CHEMBL4543348 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H8IN3O4 |
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| Mol. Mass. | 409.1355 |
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| SMILES | [O-][N+](=O)c1c(I)cccc1Oc1ccc(cc1)-c1nnco1 |
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| Structure | 
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