Reaction Details |
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Target | Sphingosine kinase 2 |
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Ligand | BDBM50514479 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1856909 (CHEMBL4357638) |
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EC50 | 84±n/a nM |
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Citation | Sibley, CD; Morris, EA; Kharel, Y; Brown, AM; Huang, T; Bevan, DR; Lynch, KR; Santos, WL Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. J Med Chem63:1178-1198 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine kinase 2 |
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Name: | Sphingosine kinase 2 |
Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
Type: | Protein |
Mol. Mass.: | 69221.44 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRA0 |
Residue: | 654 |
Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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BDBM50514479 |
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n/a |
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Name | BDBM50514479 |
Synonyms: | CHEMBL4473353 |
Type | Small organic molecule |
Emp. Form. | C24H25ClF3N5O2 |
Mol. Mass. | 507.936 |
SMILES | Cl.NC(=N)N1CCC[C@H]1c1nc(no1)-c1ccc(OCc2ccc(cc2)C(F)(F)F)c(CC=C)c1 |r| |
Structure |
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