Ki Summary

Reaction Details

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Target

Glucagon receptor

Ligand

BDBM50075763

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_72994 (CHEMBL680807)

IC50

670±n/a nM

Citation

de Laszlo, SE; Hacker, C; Li, B; Kim, D; MacCoss, M; Mantlo, N; Pivnichny, JV; Colwell, L; Koch, GE; Cascieri, MA; Hagmann, WK Potent, orally absorbed glucagon receptor antagonists. Bioorg Med Chem Lett9:641-6 (1999) [PubMed]

More Info.:

Get all data from this article, Assay Method

Glucagon receptor

Name:

Glucagon receptor

Synonyms:

GL-R | GLR_MOUSE | Gcgr

Type:

PROTEIN

Mol. Mass.:

54941.21

Organism:

Mus musculus

Description:

ChEMBL_1338729

Residue:

485

Sequence:

MPLTQLHCPHLLLLLLVLSCLPEAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCN
RTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQPWRNAS
QCQLDDEEIEVQKGVAKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGN
LFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANY
CWLLVEGVYLYSLLSLATFSERSFFSLYLGIGWGAPLLFVIPWVVVKCLFENVQCWTSND
NMGFWWILRIPVFLALLINFFIFVHIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLG
VHEVVFAFVTDEHAQGTLRSTKLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQWQ
EGKALQEERLASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASSLPRL
ADSPT

BDBM50075763

n/a

Name

BDBM50075763

Synonyms:

4-[5-(4-Chloro-phenyl)-3-(2,6-dipropoxy-phenyl)-1H-pyrrol-2-yl]-pyridine | CHEMBL347462

Type

Small organic molecule

Emp. Form.

C27H27ClN2O2

Mol. Mass.

446.968

SMILES

CCCOc1cccc(OCCC)c1-c1cc([nH]c1-c1ccncc1)-c1ccc(Cl)cc1 |(9.36,4.01,;8.87,2.56,;7.36,2.26,;6.87,.79,;5.46,.18,;4.21,1.09,;2.81,.46,;2.64,-1.08,;3.88,-1.98,;3.72,-3.51,;2.32,-4.14,;1.07,-3.23,;-.34,-3.85,;5.28,-1.36,;6.53,-2.27,;7.99,-1.8,;8.9,-3.04,;7.99,-4.29,;6.52,-3.81,;5.27,-4.7,;3.93,-3.93,;2.6,-4.7,;2.6,-6.24,;3.95,-7.01,;5.27,-6.24,;10.43,-3.06,;11.18,-4.39,;12.72,-4.39,;13.51,-3.06,;15.05,-3.06,;12.74,-1.73,;11.2,-1.73,)|

Structure