| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50524375 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1892882 (CHEMBL4394803) |
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| IC50 | 3090±n/a nM |
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| Citation |  Kumar, A; Pasam, VR; Thakur, RK; Singh, M; Singh, K; Shukla, M; Yadav, A; Dogra, S; Sona, C; Umrao, D; Jaiswal, S; Ahmad, H; Rashid, M; Singh, SK; Wahajuddin, M; Dwivedi, AK; Siddiqi, MI; Lal, J; Tripathi, RP; Yadav, PN Novel Tetrahydroquinazolinamines as Selective Histamine 3 Receptor Antagonists for the Treatment of Obesity. J Med Chem62:4638-4655 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50524375 |
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| n/a |
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| Name | BDBM50524375 |
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| Synonyms: | CHEMBL4463811 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H16BrN3 |
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| Mol. Mass. | 318.212 |
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| SMILES | CC1CCCc2c1nc(N)nc2-c1ccc(Br)cc1 |
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| Structure | 
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