Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM50531202 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1914523 (CHEMBL4417106) |
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IC50 | 49600±n/a nM |
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Citation | Han, S; Li, X; Xia, Y; Yu, Z; Cai, N; Malwal, SR; Han, X; Oldfield, E; Zhang, Y Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural-Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells. J Med Chem62:10867-10896 (2019) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM50531202 |
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n/a |
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Name | BDBM50531202 |
Synonyms: | CHEMBL4519472 |
Type | Small organic molecule |
Emp. Form. | C23H26N2O5 |
Mol. Mass. | 410.4629 |
SMILES | [H][C@@]12CC(=O)C3=C(C(=O)C(=O)C(=C3)C(C)C)[C@]1(CCCC2(C)C)c1nnc(o1)C(C)=O |r,c:11,t:5| |
Structure |
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