| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrase |
|---|
| Ligand | BDBM50087429 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_90731 (CHEMBL701283) |
|---|
| IC50 | 1200±n/a nM |
|---|
| Citation |  Zouhiri, F; Mouscadet, JF; Mekouar, K; Desmaële, D; Savouré, D; Leh, H; Subra, F; Le Bret, M; Auclair, C; d'Angelo, J Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture. J Med Chem43:1533-40 (2000) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Integrase |
|---|
| Name: | Integrase |
|---|
| Synonyms: | Human immunodeficiency virus type 1 integrase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 32231.48 |
|---|
| Organism: | Human immunodeficiency virus 1 |
|---|
| Description: | ChEMBL_90865 |
|---|
| Residue: | 288 |
|---|
| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
|
|
|
|---|
| BDBM50087429 |
|---|
| n/a |
|---|
| Name | BDBM50087429 |
|---|
| Synonyms: | (E)-2-(3,5-dibromo-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-(3,5-dibromo-4-hydroxystyryl)-8-hydroxyquinoline-7-carboxylic acid | 2-[2-(3,5-Dibromo-4-hydroxy-phenyl)-vinyl]-8-hydroxy-quinoline-7-carboxylic acid | CHEMBL39301 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11Br2NO4 |
|---|
| Mol. Mass. | 465.092 |
|---|
| SMILES | OC(=O)c1ccc2ccc(\C=C\c3cc(Br)c(O)c(Br)c3)nc2c1O |
|---|
| Structure | 
|
|---|
Search and Browse
