Reaction Details |
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Target | Cytochrome P450 2C8 |
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Ligand | BDBM50536173 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1932999 (CHEMBL4478651) |
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IC50 | >20000±n/a nM |
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Citation | Lapierre, JM; Eathiraj, S; Vensel, D; Liu, Y; Bull, CO; Cornell-Kennon, S; Iimura, S; Kelleher, EW; Kizer, DE; Koerner, S; Makhija, S; Matsuda, A; Moussa, M; Namdev, N; Savage, RE; Szwaya, J; Volckova, E; Westlund, N; Wu, H; Schwartz, B Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. J Med Chem59:6455-69 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C8 |
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Name: | Cytochrome P450 2C8 |
Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
Type: | Protein |
Mol. Mass.: | 55839.23 |
Organism: | Homo sapiens (Human) |
Description: | P10632 |
Residue: | 490 |
Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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BDBM50536173 |
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n/a |
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Name | BDBM50536173 |
Synonyms: | CHEMBL4546484 |
Type | Small organic molecule |
Emp. Form. | C26H24ClN7O |
Mol. Mass. | 485.968 |
SMILES | Cl.CC(=O)Nc1cccc(c1)-c1ccc2nc(-c3cccnc3N)n(-c3ccc(CN)cc3)c2n1 |
Structure |
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