| Reaction Details |
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 | Report a problem with these data |
| Target | Lysophosphatidic acid receptor 3 |
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| Ligand | BDBM369940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1979966 (CHEMBL4613101) |
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| IC50 | >10000±n/a nM |
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| Citation |  Cuozzo, JW; Clark, MA; Keefe, AD; Kohlmann, A; Mulvihill, M; Ni, H; Renzetti, LM; Resnicow, DI; Ruebsam, F; Sigel, EA; Thomson, HA; Wang, C; Xie, Z; Zhang, Y Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry. J Med Chem63:7840-7856 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysophosphatidic acid receptor 3 |
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| Name: | Lysophosphatidic acid receptor 3 |
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| Synonyms: | EDG7 | LPA3 | LPAR3 | LPAR3_HUMAN | Lysophosphatidic acid receptor 1/3 | Lysophosphatidic acid receptor 3 (LPAR3) | Lysophosphatidic acid receptor Edg-7 |
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| Type: | Enzyme |
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| Mol. Mass.: | 40149.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UBY5 |
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| Residue: | 353 |
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| Sequence: | MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRK
FHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNL
LVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLA
PIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKT
VMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDM
YGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
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| BDBM369940 |
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| n/a |
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| Name | BDBM369940 |
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| Synonyms: | (R)—N-(1-(1-(1H-indazol-5-yl)-3-methyl-2,4-dioxo-1,3,8-triazaspiro[4.5]decan-8-yl)-3-methyl-1-oxobutan-2-yl)-2-fluoro-5-(trifluoromethyl)benzamide | US10233182, Example 52 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28F4N6O4 |
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| Mol. Mass. | 588.5533 |
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| SMILES | CC(C)[C@@H](NC(=O)c1cc(ccc1F)C(F)(F)F)C(=O)N1CCC2(CC1)N(C(=O)N(C)C2=O)c1ccc2[nH]ncc2c1 |r| |
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| Structure | 
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