| Reaction Details |
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 | Report a problem with these data |
| Target | Urokinase-type plasminogen activator |
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| Ligand | BDBM50099920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_213135 |
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| Ki | 154±n/a nM |
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| Citation |  Subasinghe, NL; Illig, C; Hoffman, J; Rudolph, MJ; Wilson, KJ; Soll, R; Randle, T; Green, D; Lewandowski, F; Zhang, M; Bone, R; Spurlino, J; DesJarlais, R; Deckman, I; Molloy, CJ; Manthey, C; Zhou, Z; Sharp, C; Maguire, D; Crysler, C; Grasberger, B Structure-based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors. Bioorg Med Chem Lett11:1379-82 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Urokinase-type plasminogen activator |
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| Name: | Urokinase-type plasminogen activator |
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| Synonyms: | 3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA |
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| Type: | Enzyme |
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| Mol. Mass.: | 48528.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00749 |
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| Residue: | 431 |
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| Sequence: | MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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|
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| BDBM50099920 |
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| n/a |
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| Name | BDBM50099920 |
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| Synonyms: | 4-[4-(2-Chloro-pyridin-3-yl)-thiazol-2-yl]-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL285818 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11ClN4S3 |
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| Mol. Mass. | 366.912 |
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| SMILES | CSc1sc(cc1-c1nc(cs1)-c1cccnc1Cl)C(N)=N |
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| Structure | 
|
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