| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Stromelysin-1 |
|---|
| Ligand | BDBM50549079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2023907 (CHEMBL4677720) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Yamada, Y; Takashima, H; Walmsley, DL; Ushiyama, F; Matsuda, Y; Kanazawa, H; Yamaguchi-Sasaki, T; Tanaka-Yamamoto, N; Yamagishi, J; Kurimoto-Tsuruta, R; Ogata, Y; Ohtake, N; Angove, H; Baker, L; Harris, R; Macias, A; Robertson, A; Surgenor, A; Watanabe, H; Nakano, K; Mima, M; Iwamoto, K; Okada, A; Takata, I; Hitaka, K; Tanaka, A; Fujita, K; Sugiyama, H; Hubbard, RE Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J Med Chem63:14805-14820 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Stromelysin-1 |
|---|
| Name: | Stromelysin-1 |
|---|
| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 53973.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08254 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
|
|
|
|---|
| BDBM50549079 |
|---|
| n/a |
|---|
| Name | BDBM50549079 |
|---|
| Synonyms: | CHEMBL4747965 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24N4O5 |
|---|
| Mol. Mass. | 412.4391 |
|---|
| SMILES | C[C@H](O)c1nccn1Cc1cc(on1)C#Cc1ccc(OCC(N)(CO)CO)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
