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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tubulin beta-3 chain | ||
| Ligand | BDBM50005480 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2034212 (CHEMBL4688370) | ||
| IC50 | 5.7±n/a nM | ||
| Citation |  Xiang, W; Quadery, TM; Hamel, E; Luckett-Chastain, LR; Ihnat, MA; Mooberry, SL; Gangjee, A The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorg Med Chem29:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tubulin beta-3 chain | |||
| Name: | Tubulin beta-3 chain | ||
| Synonyms: | TBB3_HUMAN | TUBB3 | TUBB4 | Tubulin beta-3 chain | Tubulin beta-4 chain | Tubulin beta-III | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 50412.49 | ||
| Organism: | Homo sapiens | ||
| Description: | ChEMBL_116898 | ||
| Residue: | 450 | ||
| Sequence: |
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| BDBM50005480 | |||
| n/a | |||
| Name | BDBM50005480 | ||
| Synonyms: | (-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetramethoxystilbene | (Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | (combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | (combretastin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethox y-phenyl)-vinyl]-phenol | 2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol | 2-methoxy-5-(3,4,5-trimethoxystyryl)phenol | 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol | 5-(3,4,5-trimethoxystyryl)-2-methoxyphenol | 5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol | CHEMBL67 | Combrestatin A-4 | Combrestatin A4 | Combretastastin A-4 | Combretastatin | Combretastatin-A4 | Combretastin A-4 | Z-Combretastatin A-4 | combretastatin A-4, (CSA4) | combretastin A4 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H20O5 | ||
| Mol. Mass. | 316.3484 | ||
| SMILES | COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1O | ||
| Structure | 
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