| Reaction Details |
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 | Report a problem with these data |
| Target | Kallikrein-1 |
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| Ligand | BDBM50114449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_92367 |
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| IC50 | >11000±n/a nM |
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| Citation |  Jia, ZJ; Wu, Y; Huang, W; Goldman, E; Zhang, P; Woolfrey, J; Wong, P; Huang, B; Sinha, U; Park, G; Reed, A; Scarborough, RM; Zhu, BY Design, synthesis and biological activity of novel non-amidine factor Xa inhibitors. Part 1: P(1) structure-activity relationships of the substituted 1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides. Bioorg Med Chem Lett12:1651-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Kallikrein-1 |
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| Name: | Kallikrein-1 |
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| Synonyms: | KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein |
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| Type: | Enzyme |
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| Mol. Mass.: | 28874.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06870 |
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| Residue: | 262 |
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| Sequence: | MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWV
LTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD
LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKIL
PNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNK
PSVAVRVLSYVKWIEDTIAENS
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| BDBM50114449 |
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| n/a |
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| Name | BDBM50114449 |
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| Synonyms: | 3-[3-Methyl-5-(2'-sulfamoyl-biphenyl-4-ylcarbamoyl)-pyrazol-1-yl]-naphthalene-2-carboxylic acid methyl ester | CHEMBL298259 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H24N4O5S |
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| Mol. Mass. | 540.59 |
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| SMILES | COC(=O)c1cc2ccccc2cc1-n1nc(C)cc1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O |
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| Structure | 
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