Reaction Details |
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Target | 5-hydroxytryptamine receptor 2B |
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Ligand | BDBM472931 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2059283 (CHEMBL4714284) |
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EC50 | 316±n/a nM |
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Citation | Schrader, TO; Zhu, X; Kasem, M; Ren, A; Liu, C; Wu, C; Dang, H; Le, M; Gatlin, J; Chase, K; Frazer, J; Whelan, KT; Grottick, AJ; Hutton, C; Barden, J; Chen, C; Ortiz, A; Feichtinger, K; Semple, G Novel (R)-6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2-a][1,n]naphthyridines as potent and selective agonists of the 5-HT Bioorg Med Chem Lett38:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2B |
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Name: | 5-hydroxytryptamine receptor 2B |
Synonyms: | 5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 54312.47 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
Residue: | 481 |
Sequence: | MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
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BDBM472931 |
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n/a |
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Name | BDBM472931 |
Synonyms: | (R)-4-isobutyl-6,6a,7,8,9,10-hexahydro-5H- pyrazino[1,2-a][1,8]naphthyridine | US10836764, Compound 114 |
Type | Small organic molecule |
Emp. Form. | C15H23N3 |
Mol. Mass. | 245.3632 |
SMILES | CC(C)Cc1ccnc2N3CCNC[C@H]3CCc12 |r| |
Structure |
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