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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 2 | ||
| Ligand | BDBM50561591 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2075294 (CHEMBL4730828) | ||
| IC50 | 247±n/a nM | ||
| Citation |  Liu, H; Niu, D; Tham Sjin, RT; Dubrovskiy, A; Zhu, Z; McDonald, JJ; Fahnoe, K; Wang, Z; Munson, M; Scholte, A; Barrague, M; Fitzgerald, M; Liu, J; Kothe, M; Sun, F; Murtie, J; Ge, J; Rocnik, J; Harvey, D; Ospina, B; Perron, K; Zheng, G; Shehu, E; D'Agostino, LA Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. ACS Med Chem Lett11:1899-1904 (2020) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 2 | |||
| Name: | Fibroblast growth factor receptor 2 | ||
| Synonyms: | BEK | CD_antigen=CD332 | FGFR-2 | FGFR-2 Tyrosine Kinase | FGFR2 | FGFR2_HUMAN | Fibroblast growth factor receptor 2 (FGFR2) | Fibroblast growth factor receptor 2 precursor | KGFR | KSAM | Keratinocyte growth factor receptor | Keratinocyte growth factor receptor 2 | VEGF-receptor 2 and Fibroblast growth factor receptor 2 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 92015.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P21802 | ||
| Residue: | 821 | ||
| Sequence: |
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| BDBM50561591 | |||
| n/a | |||
| Name | BDBM50561591 | ||
| Synonyms: | CHEMBL4793510 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H25Cl2N5O4 | ||
| Mol. Mass. | 518.392 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCC[C@@H]3NC(=O)C=C)nc2n(C)c1=O |r,wU:19.19,23.25,(19.41,-17.19,;18.08,-17.97,;18.08,-19.51,;19.42,-20.27,;19.43,-21.82,;20.76,-22.6,;20.77,-24.14,;18.09,-22.6,;18.09,-24.14,;16.75,-21.82,;16.75,-20.28,;15.42,-19.51,;15.42,-22.59,;14.09,-21.81,;12.77,-22.59,;11.45,-21.8,;10.11,-22.56,;10.1,-24.1,;8.76,-24.86,;7.43,-24.09,;7.28,-22.55,;5.77,-22.22,;5,-23.55,;6.02,-24.7,;5.69,-26.21,;4.22,-26.67,;3.08,-25.64,;3.89,-28.18,;2.42,-28.65,;11.42,-24.87,;12.75,-24.12,;14.09,-24.89,;14.08,-26.43,;15.43,-24.13,;16.76,-24.9,)| | ||
| Structure | 
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