Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 7

Ligand

BDBM50157767

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2091049 (CHEMBL4772312)

35±n/a nM

Citation

Jankowska, A; Sata?a, G; Ko?aczkowski, M; Bucki, A; G?uch-Lutwin, M; ?wierczek, A; Pociecha, K; Partyka, A; Jastrz?bska-Wi?sek, M; Lubelska, A; Latacz, G; Gawalska, A; Bojarski, AJ; Wyska, E; Ch?o?-Rzepa, G Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT Eur J Med Chem201:0 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 7

Name:

5-hydroxytryptamine receptor 7

Synonyms:

5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-Hydroxytryptamine receptor 7 (5-HT7) | 5-hydroxytryptamine receptor 7 | 5-hydroxytryptamine receptor 7 (5-HT-7) | 5HT7R_RAT | Adrenergic Alpha | GPRFO | Htr7 | Serotonin (5-HT) receptor | Serotonin Receptor 7

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

49852.62

Organism:

Rattus norvegicus (rat)

Description:

Rat cloned 5-HT7R.

Residue:

448

Sequence:

MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPA
PTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSN
YLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVIS
IDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDF
GYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQK
EVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTS
CSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHE
ALKLAERPERSEFVLQNSDHCGKKGHDT

BDBM50157767

n/a

Name

BDBM50157767

Synonyms:

CHEMBL376662 | N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-4-(2-methoxyphenyl)-1-piperazinebutanamide

Type

Small organic molecule

Emp. Form.

C26H35N3O3

Mol. Mass.

437.5744

SMILES

COc1cccc2C(CCCc12)NC(=O)CCCN1CCN(CC1)c1ccccc1OC

Structure