| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycogen phosphorylase, liver form |
|---|
| Ligand | BDBM50136446 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_99041 |
|---|
| IC50 | 45±n/a nM |
|---|
| Citation |  Rosauer, KG; Ogawa, AK; Willoughby, CA; Ellsworth, KP; Geissler, WM; Myers, RW; Deng, Q; Chapman, KT; Harris, G; Moller, DE Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a. Bioorg Med Chem Lett13:4385-8 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycogen phosphorylase, liver form |
|---|
| Name: | Glycogen phosphorylase, liver form |
|---|
| Synonyms: | Glycogen Phosphorylase (PYGL) | Glycogen Phosphorylase, liver form | Liver glycogen phosphorylase | PYGL | PYGL_HUMAN |
|---|
| Type: | Homodimer |
|---|
| Mol. Mass.: | 97153.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Dimers associate into a tetramer to form the enzymatically active phosphorylase A. |
|---|
| Residue: | 847 |
|---|
| Sequence: | MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
|
|
|
|---|
| BDBM50136446 |
|---|
| n/a |
|---|
| Name | BDBM50136446 |
|---|
| Synonyms: | 1-{(S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3-phenyl-propionyl}-azetidine-3-carboxylic acid | CHEMBL335954 | CP-403,700 | CP-403700 | [5-CHLORO-1H-INDOL-2-CARBONYL-PHENYLALANINYL]-AZETIDINE-3-CARBOXYLIC ACID |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H20ClN3O4 |
|---|
| Mol. Mass. | 425.865 |
|---|
| SMILES | OC(=O)C1CN(C1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
