Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Platelet-derived growth factor receptor beta | ||
| Ligand | BDBM50575344 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2125050 (CHEMBL4834283) | ||
| IC50 | >11000±n/a nM | ||
| Citation |  Mathison, CJN; Yang, Y; Nelson, J; Huang, Z; Jiang, J; Chianelli, D; Rucker, PV; Roland, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- ACS Med Chem Lett12:1912-1919 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Platelet-derived growth factor receptor beta | |||
| Name: | Platelet-derived growth factor receptor beta | ||
| Synonyms: | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF Receptor Substrate | PDGF-R-beta | PDGFR | PDGFR substrate | PDGFR-1 | PDGFR1 | PDGFRB | PDGFRbeta | PGFRB_HUMAN | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta | Platelet-derived growth factor receptor beta (PDGFR-beta) | Platelet-derived growth factor receptor beta (PDGFRB) | Platelet-derived growth factor receptor beta (PDGFRbeta) | VHL/PDGFRB | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 123922.25 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P09619 | ||
| Residue: | 1106 | ||
| Sequence: |
| ||
| BDBM50575344 | |||
| n/a | |||
| Name | BDBM50575344 | ||
| Synonyms: | CHEMBL4854822 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25FN6O2 | ||
| Mol. Mass. | 424.4713 | ||
| SMILES | CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cc(O)ccc2F)c2c(N)ncnc12 |r,wU:11.14,9.9,(5.38,-23.19,;6.89,-22.87,;7.92,-24.01,;7.36,-21.4,;6.33,-20.26,;6.8,-18.8,;8.31,-18.48,;9.35,-19.61,;8.87,-21.08,;8.78,-17.01,;8.08,-15.64,;9.45,-14.94,;10.15,-16.31,;9.91,-13.47,;9,-12.23,;9.9,-10.98,;9.42,-9.52,;10.45,-8.37,;9.97,-6.91,;11,-5.76,;8.46,-6.59,;7.43,-7.75,;7.92,-9.21,;6.9,-10.36,;11.37,-11.45,;12.7,-10.67,;12.7,-9.13,;14.04,-11.43,;14.05,-12.98,;12.71,-13.76,;11.37,-12.99,)| | ||
| Structure | 
| ||