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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | BDNF/NT-3 growth factors receptor | ||
| Ligand | BDBM50575344 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2125057 (CHEMBL4834290) | ||
| IC50 | 8500±n/a nM | ||
| Citation |  Mathison, CJN; Yang, Y; Nelson, J; Huang, Z; Jiang, J; Chianelli, D; Rucker, PV; Roland, J; Xie, YF; Epple, R; Bursulaya, B; Lee, C; Gao, MY; Shaffer, J; Briones, S; Sarkisova, Y; Galkin, A; Li, L; Li, N; Li, C; Hua, S; Kasibhatla, S; Kinyamu-Akunda, J; Kikkawa, R; Molteni, V; Tellew, JE Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3- ACS Med Chem Lett12:1912-1919 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| BDNF/NT-3 growth factors receptor | |||
| Name: | BDNF/NT-3 growth factors receptor | ||
| Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 91996.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q16620 | ||
| Residue: | 822 | ||
| Sequence: |
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| BDBM50575344 | |||
| n/a | |||
| Name | BDBM50575344 | ||
| Synonyms: | CHEMBL4854822 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25FN6O2 | ||
| Mol. Mass. | 424.4713 | ||
| SMILES | CC(=O)N1CCN(CC1)[C@H]1C[C@H](C1)n1cc(-c2cc(O)ccc2F)c2c(N)ncnc12 |r,wU:11.14,9.9,(5.38,-23.19,;6.89,-22.87,;7.92,-24.01,;7.36,-21.4,;6.33,-20.26,;6.8,-18.8,;8.31,-18.48,;9.35,-19.61,;8.87,-21.08,;8.78,-17.01,;8.08,-15.64,;9.45,-14.94,;10.15,-16.31,;9.91,-13.47,;9,-12.23,;9.9,-10.98,;9.42,-9.52,;10.45,-8.37,;9.97,-6.91,;11,-5.76,;8.46,-6.59,;7.43,-7.75,;7.92,-9.21,;6.9,-10.36,;11.37,-11.45,;12.7,-10.67,;12.7,-9.13,;14.04,-11.43,;14.05,-12.98,;12.71,-13.76,;11.37,-12.99,)| | ||
| Structure | 
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