Reaction Details |
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Target | C-1-tetrahydrofolate synthase, cytoplasmic |
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Ligand | BDBM50580115 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2147065 (CHEMBL5031411) |
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IC50 | >10000±n/a nM |
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Citation | Lee, LC; Peng, YH; Chang, HH; Hsu, T; Lu, CT; Huang, CH; Hsueh, CC; Kung, FC; Kuo, CC; Jiaang, WT; Wu, SY Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J Med Chem64:11288-11301 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-1-tetrahydrofolate synthase, cytoplasmic |
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Name: | C-1-tetrahydrofolate synthase, cytoplasmic |
Synonyms: | 1.5.1.5 | 3.5.4.9 | 6.3.4.3 | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | C1-THF synthase | C1TC_HUMAN | Epididymis secretory sperm binding protein | Formyltetrahydrofolate synthetase | MTHFC | MTHFD | MTHFD1 | Methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase |
Type: | PROTEIN |
Mol. Mass.: | 101538.58 |
Organism: | Homo sapiens |
Description: | ChEMBL_11303 |
Residue: | 935 |
Sequence: | MAPAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAA
EEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAP
EKDVDGLTSINAGKLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAP
MHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY
VPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLEKFKP
GKWMIQYNNLNLKTPVPSDIDISRSCKPKPIGKLAREIGLLSEEVELYGETKAKVLLSAL
ERLKHRPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLYQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARIFHELTQTDKALFNRLV
PSVNGVRRFSDIQIRRLKRLGIEKTDPTTLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHTRTAQFDISVASEIMAVLALTTSLEDMRERLGKMVVASSKKGEPV
SAEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PEGFVVTEAGFGADIGMEKFFNIKCRYSGLCPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIQENLELVEKGFSNLKKQIENARMFGIPVVVAVNAFKTDTESELDLISRLSREHGAF
DAVKCTHWAEGGKGALALAQAVQRAAQAPSSFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPEQKGVPTGFILPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
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BDBM50580115 |
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n/a |
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Name | BDBM50580115 |
Synonyms: | CHEMBL5084848 |
Type | Small organic molecule |
Emp. Form. | C25H22Cl2N6O7 |
Mol. Mass. | 589.384 |
SMILES | Cn1c(Nc2ccc(cc2)C(=O)N[C@@H](CC(O)=O)C(O)=O)nc2n(C)c(=O)n(Cc3ccc(Cl)c(Cl)c3)c(=O)c12 |r| |
Structure |
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