Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Polyamine deacetylase HDAC10 |
---|
Ligand | BDBM29589 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2159154 (CHEMBL5043904) |
---|
IC50 | 2.3±n/a nM |
---|
Citation | Jiang, Y; Xu, J; Yue, K; Huang, C; Qin, M; Chi, D; Yu, Q; Zhu, Y; Hou, X; Xu, T; Li, M; Chou, CJ; Li, X Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo. J Med Chem65:285-302 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Polyamine deacetylase HDAC10 |
---|
Name: | Polyamine deacetylase HDAC10 |
Synonyms: | HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 71431.89 |
Organism: | Homo sapiens (Human) |
Description: | Q969S8 |
Residue: | 669 |
Sequence: | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEEL
GLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTG
AVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQ
YLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVA
AFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAV
LEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQ
DVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPD
ITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIA
ATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALS
MFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGL
AGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKM
LQCHPHLVA
|
|
|
BDBM29589 |
---|
n/a |
---|
Name | BDBM29589 |
Synonyms: | Faridak | LBH-589 | LBH-589B | Panobinostat | US10722597, Compound Panobinostat |
Type | Small organic molecule |
Emp. Form. | C21H23N3O2 |
Mol. Mass. | 349.4262 |
SMILES | Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1 |
Structure |
|