| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Pantetheinase |
|---|
| Ligand | BDBM480928 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2162817 (CHEMBL5047678) |
|---|
| IC50 | 25±n/a nM |
|---|
| Citation |  Casimiro-Garcia, A; Allais, C; Brennan, A; Choi, C; Dower, G; Farley, KA; Fleming, M; Flick, A; Frisbie, RK; Hall, J; Hepworth, D; Jones, H; Knafels, JD; Kortum, S; Lovering, FE; Mathias, JP; Mohan, S; Morgan, PM; Parng, C; Parris, K; Pullen, N; Schlerman, F; Stansfield, J; Strohbach, JW; Vajdos, FF; Vincent, F; Wang, H; Wang, X; Webster, R; Wright, SW Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem65:757-784 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Pantetheinase |
|---|
| Name: | Pantetheinase |
|---|
| Synonyms: | 3.5.1.92 | Pantetheine hydrolase | VNN1_MOUSE | Vanin-1 | Vascular non-inflammatory molecule 1 | Vnn1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 57084.66 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_120311 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MGMSWWLACAAAFSALCVLKASSLDTFLAAVYEHAVILPKDTLLPVSHSEALALMNQNLD
LLEGAIVSAAKQGAHIIVTPEDGIYGVRFTRDTIYPYLEEIPDPQVNWIPCDNPKRFGST
PVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSQGKLVARYHK
QNIFMGEDQFNVPMEPEFVTFDTPFGKFGVFTCFDILFHDPAVTLVTEFQVDTILFPTAW
MDVLPHLAAIEFHSAWAMGMGVNFLAANLHNPSRRMTGSGIYAPDSPRVFHYDRKTQEGK
LLFAQLKSHPIHSPVNWTSYASSVESTPTKTQEFQSIVFFDEFTFVELKGIKGNYTVCQN
DLCCHLSYQMSEKRADEVYAFGAFDGLHTVEGQYYLQICILLKCKTTNLRTCGSSVDTAF
TRFEMFSLSGTFGTRYVFPEVLLSEVKLAPGEFQVSSDGRLVSLKPTSGPVLTIGLFGRL
YGKDWASNASSDFIAHSLIIMLIVTPIIHYLC
|
|
|
|---|
| BDBM480928 |
|---|
| n/a |
|---|
| Name | BDBM480928 |
|---|
| Synonyms: | 8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}methanone | US10906888, Example 142 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H22N6O2 |
|---|
| Mol. Mass. | 354.4063 |
|---|
| SMILES | O=C(N1CCC2(C1)CCOCC2)c1cnc(NCc2cnccn2)nc1 |
|---|
| Structure | 
|
|---|
Search and Browse
