Ki Summary

Reaction Details

Report a problem with these data

Target

Gonadotropin-releasing hormone receptor

Ligand

BDBM50160236

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_303515 (CHEMBL839629)

220±n/a nM

Citation

Guo, Z; Wu, D; Zhu, YF; Tucci, FC; Pontillo, J; Saunders, J; Xie, Q; Struthers, RS; Chen, C A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists. Bioorg Med Chem Lett15:693-8 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gonadotropin-releasing hormone receptor

Name:

Gonadotropin-releasing hormone receptor

Synonyms:

Type:

Enzyme

Mol. Mass.:

37749.45

Organism:

Homo sapiens (Human)

Description:

P30968

Residue:

328

Sequence:

MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL

BDBM50160236

n/a

Name

BDBM50160236

Synonyms:

1-((R)-2-Amino-2-phenyl-ethyl)-3-(2,6-difluoro-benzyl)-5-(2,6-difluoro-phenyl)-[1,3,5]triazinane-2,4,6-trione | CHEMBL182145

Type

Small organic molecule

Emp. Form.

C24H18F4N4O3

Mol. Mass.

486.4183

SMILES

N[C@@H](Cn1c(=O)n(Cc2c(F)cccc2F)c(=O)n(-c2c(F)cccc2F)c1=O)c1ccccc1 |wD:1.0,(-2.88,-.17,;-2.88,1.33,;-1.56,2.1,;-.25,1.33,;-.25,-.22,;-1.58,-.98,;1.21,-1.02,;1.21,-3.98,;-.13,-4.74,;-.13,-6.31,;1.21,-7.07,;-1.47,-7.07,;-2.81,-6.31,;-2.81,-4.76,;-1.47,-3.98,;-1.49,-2.45,;2.41,-.22,;3.75,-.97,;2.41,1.33,;3.77,2.12,;3.77,3.65,;2.43,4.4,;5.08,4.42,;6.45,3.64,;6.42,2.09,;5.08,1.33,;5.08,-.19,;1.09,2.12,;1.09,3.66,;-4.19,2.09,;-5.51,1.33,;-6.82,2.07,;-6.85,3.62,;-5.51,4.38,;-4.19,3.62,)|

Structure