Reaction Details |
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Target | High affinity nerve growth factor receptor |
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Ligand | BDBM50593040 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2206794 (CHEMBL5119502) |
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IC50 | 13±n/a nM |
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Citation | Ito, T; Kinoshita, K; Tomizawa, M; Shinohara, S; Nishii, H; Matsushita, M; Hattori, K; Kohchi, Y; Kohchi, M; Hayase, T; Watanabe, F; Hasegawa, K; Tanaka, H; Kuramoto, S; Takanashi, K; Oikawa, N Discovery of CH7057288 as an Orally Bioavailable, Selective, and Potent pan-TRK Inhibitor. J Med Chem65:12427-12444 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity nerve growth factor receptor |
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Name: | High affinity nerve growth factor receptor |
Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
Type: | n/a |
Mol. Mass.: | 87498.18 |
Organism: | Homo sapiens (Human) |
Description: | P04629 |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
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BDBM50593040 |
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n/a |
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Name | BDBM50593040 |
Synonyms: | CHEMBL5189733 |
Type | Small organic molecule |
Emp. Form. | C36H33N3O6 |
Mol. Mass. | 603.6637 |
SMILES | CC1(C)NC(=O)N(CCOc2ccc3C(=O)c4c(oc5cc(ccc45)C#Cc4cc(OCC5CC5)ccn4)C(C)(C)c3c2)C1=O |
Structure |
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