| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50171148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321466 (CHEMBL880407) |
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| IC50 | 10000±n/a nM |
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| Citation |  Laufersweiler, MC; Wang, Y; Soper, DL; Suchanek, MK; Fancher, AN; Lu, W; Wang, RL; Oppong, KA; Ellis, CD; Baize, MW; O'Neil, SV; Wos, JA; Demuth, TP Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme. Bioorg Med Chem Lett15:4322-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50171148 |
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| n/a |
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| Name | BDBM50171148 |
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| Synonyms: | (S)-9-Oxo-1,2,3,9-tetrahydro-pyrrolo[2,1-b]quinazoline-1-carboxylic acid ((S)-2-hydroxy-5-oxo-tetrahydro-furan-3-yl)-amide | CHEMBL197926 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H15N3O5 |
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| Mol. Mass. | 329.3074 |
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| SMILES | OC1OC(=O)C[C@@H]1NC(=O)[C@@H]1CCc2nc3ccccc3c(=O)n12 |
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| Structure | 
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