| Reaction Details |
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 | Report a problem with these data |
| Target | Sentrin-specific protease 1 |
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| Ligand | BDBM50148911 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2230467 (CHEMBL5144239) |
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| IC50 | 2580±n/a nM |
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| Citation |  Wei, H; Guo, J; Sun, X; Gou, W; Ning, H; Fang, Z; Liu, Q; Hou, W; Li, Y Discovery and radiosensitization research of ursolic acid derivatives as SENP1 inhibitors. Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sentrin-specific protease 1 |
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| Name: | Sentrin-specific protease 1 |
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| Synonyms: | SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1) |
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| Type: | Protein |
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| Mol. Mass.: | 73500.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9P0U3 |
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| Residue: | 644 |
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| Sequence: | MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTC
STRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYL
ETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVS
TAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNS
CASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPH
QPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQI
EEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEF
PEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLME
RSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVD
FRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNG
SDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
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| BDBM50148911 |
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| n/a |
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| Name | BDBM50148911 |
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| Synonyms: | (3beta)-3-hydroxyurs-12-en-28-oic acid | 3beta-hydroxyurs-12-en-28-oic acid | CHEMBL169 | Ursolic acid | malol | prunol | urson |
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| Type | Small organic molecule |
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| Emp. Form. | C30H48O3 |
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| Mol. Mass. | 456.7003 |
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| SMILES | C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9| |
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| Structure | 
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