| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 6 |
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| Ligand | BDBM50601003 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2235663 (CHEMBL5149435) |
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| EC50 | >10000±n/a nM |
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| Citation |  Yuan, G; Dhaynaut, M; Guehl, NJ; Afshar, S; Huynh, D; Moon, SH; Iyengar, SM; Jain, MK; Pickett, JE; Kang, HJ; Ondrechen, MJ; El Fakhri, G; Normandin, MD; Brownell, AL Design, Synthesis, and Characterization of [ J Med Chem65:9939-9954 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 6 |
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| Name: | Metabotropic glutamate receptor 6 |
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| Synonyms: | GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 95479.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 6 GRM6 HUMAN::O15303 |
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| Residue: | 877 |
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| Sequence: | MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQL
KKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGR
GDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPE
LSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREA
GGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGH
FLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEF
WEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQ
ALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG
SASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHC
EACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVAT
TTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLG
TTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARP
PHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFN
EAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKT
YVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
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| BDBM50601003 |
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| n/a |
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| Name | BDBM50601003 |
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| Synonyms: | CHEMBL5179002 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22F5N5 |
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| Mol. Mass. | 451.4356 |
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| SMILES | Fc1ccc(N2CCN(Cc3cc(cn4c(CC5CC5)nnc34)C(F)(F)F)CC2)c(F)c1 |
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| Structure | 
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