| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 3 |
|---|
| Ligand | BDBM50187283 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_357374 (CHEMBL854259) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Wright, SW; Ammirati, MJ; Andrews, KM; Brodeur, AM; Danley, DE; Doran, SD; Lillquist, JS; McClure, LD; McPherson, RK; Orena, SJ; Parker, JC; Polivkova, J; Qiu, X; Soeller, WC; Soglia, CB; Treadway, JL; VanVolkenburg, MA; Wang, H; Wilder, DC; Olson, TV cis-2,5-dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization. J Med Chem49:3068-76 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 3 |
|---|
| Name: | Dipeptidyl peptidase 3 |
|---|
| Synonyms: | DPP3 | DPP3_HUMAN | Dipeptidyl arylamidase III | Dipeptidyl peptidase 3 | Dipeptidyl peptidase III | Dipeptidyl peptidase III (DPP III) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 82565.94 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NY33 |
|---|
| Residue: | 737 |
|---|
| Sequence: | MADTQYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSPEAPYIY
ALLSRLFRAQDPDQLRQHALAEGLTEEEYQAFLVYAAGVYSNMGNYKSFGDTKFVPNLPK
EKLERVILGSEAAQQHPEEVRGLWQTCGELMFSLEPRLRHLGLGKEGITTYFSGNCTMED
AKLAQDFLDSQNLSAYNTRLFKEVDGEGKPYYEVRLASVLGSEPSLDSEVTSKLKSYEFR
GSPFQVTRGDYAPILQKVVEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFW
IQDKGPIVESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELPWP
PTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVSLGNVLAVAYATQ
REKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSGKLFVQDEKGAFNFDQETVINPE
TGEQIQSWYRSGETWDSKFSTIASSYEECRAESVGLYLCLHPQVLEIFGFEGADAEDVIY
VNWLNMVRAGLLALEFYTPEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPD
ARVRLDRSKIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTLRD
TVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDGPELEEILTQLAT
ADARFWKGPSEAPSGQA
|
|
|
|---|
| BDBM50187283 |
|---|
| n/a |
|---|
| Name | BDBM50187283 |
|---|
| Synonyms: | (2R,5S)-1-(2-(1-(ethoxymethyl)cyclopentylamino)acetyl)pyrrolidine-2,5-dicarbonitrile | CHEMBL209191 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H24N4O2 |
|---|
| Mol. Mass. | 304.3874 |
|---|
| SMILES | CCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N |
|---|
| Structure | 
|
|---|
Search and Browse
