Reaction Details |
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Target | Mast/stem cell growth factor receptor Kit |
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Ligand | BDBM50188748 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_390503 (CHEMBL869849) |
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IC50 | 17±n/a nM |
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Citation | Dinges, J; Ashworth, KL; Akritopoulou-Zanze, I; Akritopolou-Zanze, I; Arnold, LD; Baumeister, SA; Bousquet, PF; Cunha, GA; Davidsen, SK; Djuric, SW; Gracias, VJ; Michaelides, MR; Rafferty, P; Sowin, TJ; Stewart, KD; Xia, Z; Zhang, HQ 1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett16:4266-71 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mast/stem cell growth factor receptor Kit |
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Name: | Mast/stem cell growth factor receptor Kit |
Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
Type: | Protein |
Mol. Mass.: | 109869.37 |
Organism: | Homo sapiens (Human) |
Description: | P10721 |
Residue: | 976 |
Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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BDBM50188748 |
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n/a |
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Name | BDBM50188748 |
Synonyms: | 1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)-3-(3-(trifluoromethyl)phenyl)urea | CHEMBL212986 |
Type | Small organic molecule |
Emp. Form. | C29H29F3N6OS |
Mol. Mass. | 566.64 |
SMILES | CN1CCN(Cc2ccc-3c(Cc4c-3n[nH]c4-c3ccc(CNC(=O)Nc4cccc(c4)C(F)(F)F)s3)c2)CC1 |
Structure |
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